Literature DB >> 11843599

Concise, regioselective synthesis of the ABC tristetrahydropyran of thyrsiferol and venustatriol.

Frank E McDonald1, Xudong Wei.   

Abstract

[structure: see text] The ABC tristetrahydropyran substructure 1 of the natural products thyrsiferol (2) and venustatriol (3) has been synthesized in 14 steps from farnesyl acetate, with effective control of all aspects of regio- and stereoselectivity in the formation of each tetrahydropyran ring.

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Year:  2002        PMID： 11843599     DOI： 10.1021/ol0171968

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Thyrsiferol Inhibits Mitochondrial Respiration and HIF-1 Activation.

Authors:  Fakhri Mahdi; Miriam Falkenberg; Efstathia Ioannou; Vassilios Roussis; Yu-Dong Zhou; Dale G Nagle
Journal:  Phytochem Lett       Date:  2011-06       Impact factor: 1.679

2.  Total synthesis of the protein phosphatase 2A inhibitor lactodehydrothyrsiferol.

Authors:  Dane J Clausen; Shuangyi Wan; Paul E Floreancig
Journal:  Angew Chem Int Ed Engl       Date:  2011-04-21       Impact factor: 15.336

3.  Enantiospecific Solvolytic Functionalization of Bromochlorides.

Authors:  Alexander J Burckle; Bálint Gál; Frederick J Seidl; Vasil H Vasilev; Noah Z Burns
Journal:  J Am Chem Soc       Date:  2017-09-18       Impact factor: 15.419
  3 in total

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