Literature DB >> 11843589

An efficient route to alkyl chlorides from alcohols using the complex TCT/DMF.

Lidia De Luca1, Giampaolo Giacomelli, Andrea Porcheddu.   

Abstract

[reaction: see text] Efficient conversion of alcohols and beta-amino alcohols to the corresponding chlorides (and bromides) can be carried out at room temperature in methylene chloride, using 2,4,6-trichloro[1,3,5]triazine and N,N-dimethyl formamide. This procedure can also be applied to optically active carbinols.

Entities:  

Year:  2002        PMID： 11843589     DOI： 10.1021/ol017168p

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  14 in total

1.  Enantiospecific total synthesis of the hapalindoles, fischerindoles, and welwitindolinones via a redox economic approach.

Authors:  Jeremy M Richter; Yoshihiro Ishihara; Takeshi Masuda; Brandon W Whitefield; Tomás Llamas; Antti Pohjakallio; Phil S Baran
Journal:  J Am Chem Soc       Date:  2008-12-31       Impact factor: 15.419

2.  Synthesis, Characterization, and in vitro Testing of a Bacteria-Targeted MR Contrast Agent.

Authors:  Lauren M Matosziuk; Allison S Harney; Keith W Macrenaris; Thomas J Meade
Journal:  Eur J Inorg Chem       Date:  2012-04       Impact factor: 2.524

3.  The Michael addition of indoles and pyrrole to alpha-, beta-unsaturated ketones and double-conjugate 1,4-addition of indoles to symmetric enones promoted by pulverization-activation method and Thia-Michael addition catalyzed by wet cyanuric chloride.

Authors:  Ramin Ghorbani-Vaghei; Hojat Veisi
Journal:  Mol Divers       Date:  2009-08-07       Impact factor: 2.943

4.  Synthesis and biological evaluation of C-2 halogenated analogs of salvinorin A.

Authors:  David Y W Lee; Lu Yang; Wei Xu; Gang Deng; Lin Guo; Lee-Yuan Liu-Chen
Journal:  Bioorg Med Chem Lett       Date:  2010-08-05       Impact factor: 2.823

Review 5.  Chemoselective hydroxyl group transformation: an elusive target.

Authors:  Darci J Trader; Erin E Carlson
Journal:  Mol Biosyst       Date:  2012-10

6.  Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents.

Authors:  Lan Xie; Masuo Goto; Xiaoyan Chen; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  ACS Med Chem Lett       Date:  2021-11-17       Impact factor: 4.345

7.  Synthesis of 2,4,6-tri-substituted-1,3,5-triazines.

Authors:  Carlos A M Afonso; Nuno M T Lourenço; Andreia de A Rosatella
Journal:  Molecules       Date:  2006-01-31       Impact factor: 4.411

8.  High-load, oligomeric dichlorotriazine: a versatile ROMP-derived reagent and scavenger.

Authors:  Alan Rolfe; Donald A Probst; Kelly A Volp; Iman Omar; Daniel L Flynn; Paul R Hanson
Journal:  J Org Chem       Date:  2008-10-21       Impact factor: 4.354

9.  Synthesis of a phosphonate-linked aminoglycoside-coenzyme a bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance.

Authors:  Feng Gao; Xuxu Yan; Karine Auclair
Journal:  Chemistry       Date:  2009       Impact factor: 5.236

10.  Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus.

Authors:  Na Liu; Lei Wei; Li Huang; Fei Yu; Weifan Zheng; Bingjie Qin; Dong-Qin Zhu; Susan L Morris-Natschke; Shibo Jiang; Chin-Ho Chen; Kuo-Hsiung Lee; Lan Xie
Journal:  J Med Chem       Date:  2016-04-12       Impact factor: 7.446
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