Literature DB >> 11842320

Antioxidant effects of 1,5-anhydro-D-fructose, a new natural sugar, in vitro.

Kazuyo Yamaji1, Krishna Pada Sarker, Ikuro Maruyama, Susumu Hizukuri.   

Abstract

The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.

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Year:  2002        PMID： 11842320     DOI： 10.1055/s-2002-20050

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  4 in total

1.  1,5-Anhydro-D-fructose: A natural antibiotic that inhibits the growth of gram-positive bacteria and microbial biofilm formation to prevent nosocomial infection.

Authors:  Xiaojie Meng; Ko-Ichi Kawahara; Hiroaki Miyanohara; Yasushi Yoshimoto; Kazuhiro Yoshinaga; Satoshi Noma; Kiyoshi Kikuchi; Yoko Morimoto; Takashi Ito; Yoko Oyama; Narimasa Yoshinaga; Binita Shrestha; Binita Chandan; Kentaro Mera; Ko-Ichi Tada; Naoki Miura; Yoshiko Ono; Kazunori Takenouchi; Ryuichi Maenosono; Tomoka Nagasato; Teruto Hashiguchi; Ikuro Maruyama
Journal:  Exp Ther Med       Date:  2011-04-01       Impact factor: 2.447

2.  Study on administration of 1,5-anhydro-D-fructose in C57BL/6J mice challenged with high-fat diet.

Authors:  Jie Mei; Shukun Yu; Bo Ahrén
Journal:  BMC Endocr Disord       Date:  2010-10-19       Impact factor: 2.763

3.  A Possibility of Simultaneous Treatment with the Multicomponent Drug, Ninjin'yoeito, for Anorexia, Apathy, and Cognitive Dysfunction in Frail Alzheimer's Disease Patients: An Open-Label Pilot Study.

Authors:  Makoto Ohsawa; Yukiko Tanaka; Yoshito Ehara; Setsuko Makita; Kosuke Onaka
Journal:  J Alzheimers Dis Rep       Date:  2017-12-09

4.  Potential roles of 1,5-anhydro-D-fructose in modulating gut microbiome in mice.

Authors:  Takashi Ito; Takaaki Totoki; Seiya Takada; Shotaro Otsuka; Ikuro Maruyama
Journal:  Sci Rep       Date:  2021-10-04       Impact factor: 4.379
  4 in total

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