Literature DB >> 11842079

Selected contribution: circadian rhythm of tumor necrosis factor-alpha uptake into mouse spinal cord.

Weihong Pan1, Germaine Cornélissen, Franz Halberg, Abba J Kastin.   

Abstract

Circadian variations in the actions of tumor necrosis factor-alpha (TNF-alpha) have been observed. Because a saturable transport system at the blood-brain barrier mediates most of the influx of TNF-alpha from blood to the central nervous system (CNS), the circadian variation of the CNS effects of TNF-alpha could be related to changes in this transport system. Accordingly, we measured the uptake of intravenously injected TNF-alpha into various CNS regions at different times and compared these measurements with the uptake into a peripheral control (muscle). We found that the spinal cord, but not the brain, showed a circadian rhythm in the uptake of TNF-alpha. This pattern is similar to that of leptin but different from that of interleukin-1. The circadian rhythm of the influx of TNF-alpha into this region of the CNS suggests a functional role for the spinal cord in the physiological actions of TNF-alpha.

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Year:  2002        PMID： 11842079     DOI： 10.1152/japplphysiol.00915.2001

Source DB:  PubMed          Journal:  J Appl Physiol (1985)        ISSN： 0161-7567


  9 in total

Review 1.  Adipokines and the blood-brain barrier.

Authors:  Weihong Pan; Abba J Kastin
Journal:  Peptides       Date:  2007-05-06       Impact factor: 3.750

2.  Sleep restriction impairs blood-brain barrier function.

Authors:  Junyun He; Hung Hsuchou; Yi He; Abba J Kastin; Yuping Wang; Weihong Pan
Journal:  J Neurosci       Date:  2014-10-29       Impact factor: 6.167

Review 3.  Neuroimmune Axes of the Blood-Brain Barriers and Blood-Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions.

Authors:  Michelle A Erickson; William A Banks
Journal:  Pharmacol Rev       Date:  2018-04       Impact factor: 25.468

4.  IL-15 receptor deletion results in circadian changes of locomotor and metabolic activity.

Authors:  Yi He; Xiaojun Wu; Reas S Khan; Abba J Kastin; Germaine G Cornelissen-Guillaume; Hung Hsuchou; Barry Robert; Franz Halberg; Weihong Pan
Journal:  J Mol Neurosci       Date:  2009-12-10       Impact factor: 3.444

Review 5.  Regulation of the Blood-Brain Barrier by Circadian Rhythms and Sleep.

Authors:  Vishnu Anand Cuddapah; Shirley L Zhang; Amita Sehgal
Journal:  Trends Neurosci       Date:  2019-07       Impact factor: 13.837

6.  A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux.

Authors:  Shirley L Zhang; Zhifeng Yue; Denice M Arnold; Gregory Artiushin; Amita Sehgal
Journal:  Cell       Date:  2018-03-08       Impact factor: 41.582

7.  Does Transcranial Direct Current Stimulation Combined with Peripheral Electrical Stimulation Have an Additive Effect in the Control of Hip Joint Osteonecrosis Pain Associated with Sickle Cell Disease? A Protocol for a One-Session Double Blind, Block-Randomized Clinical Trial.

Authors:  Tiago da Silva Lopes; Wellington Dos Santos Silva; Sânzia B Ribeiro; Camila A Figueiredo; Fernanda Q Campbell; Gildasio de Cerqueira Daltro; Antônio Valenzuela; Pedro Montoya; Rita de C S Lucena; Abrahão F Baptista
Journal:  Front Hum Neurosci       Date:  2017-12-20       Impact factor: 3.169

8.  A circadian clock regulates efflux by the blood-brain barrier in mice and human cells.

Authors:  Shirley L Zhang; Nicholas F Lahens; Zhifeng Yue; Denice M Arnold; Peter P Pakstis; Jessica E Schwarz; Amita Sehgal
Journal:  Nat Commun       Date:  2021-01-27       Impact factor: 14.919

9.  Improved locomotor recovery after contusive spinal cord injury in Bmal1-/- mice is associated with protection of the blood spinal cord barrier.

Authors:  Lukasz P Slomnicki; Scott A Myers; Sujata Saraswat Ohri; Molly V Parsh; Kariena R Andres; Julia H Chariker; Eric C Rouchka; Scott R Whittemore; Michal Hetman
Journal:  Sci Rep       Date:  2020-08-26       Impact factor: 4.379
  9 in total

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