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Literature DB >> 1184195

[Experimental study in rats on the renal compatibility of cephalothin and cephalothin-aminoglycoside combinations (author's transl)].

Abstract

The possible nephrotoxity of cephalothin and the antibiotic combinations cephalotin-gentamicin and cephalothin-tobramycin was investigated in standardized animal experiments. Toxicity parameters were blood-urea concentration, the urinary enzymes GOT, LDH, MDH and the cell excretion rate, supplemented by histological investigations of the kidneys. Compared with other cephalosporine derivates, the antibiotic cephalothin in a toxic threshold-dose of 3000 mg/kg/day proved to be realtively well tolerated by the kidneys. On comparison with the respective monotherapy, the renal tolerance for cephalothin-aminoglycoside combinations was reduced. The clinical value of these findings is discussed.

Entities: Chemical Disease Species

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Year: 1975 PMID： 1184195 DOI： 10.1007/bf01641048

Source DB: PubMed Journal: Infection ISSN： 0300-8126 Impact factor: 3.553

30 in total

[Experimental study in rats on the renal compatibility of cephalothin and cephalothin-aminoglycoside combinations (author's transl)].

1. [Acute kidney failure caused by cephalothin?].

2. [Acute renal failure during treatment with gentamicin and cephalothin].

3. [Acute renal failure following gentamicin-cephalosporin association therapy].

4. Failure to demonstrate nephrotoxicity of cephalothin in rabbits with reduced renal function.

5. [Animal experiment and clinical studies on the nephrotoxicity of cephaloridine].

6. Treatment of bacterial endocarditis with cephalothin.

7. Enhancement by potent diuretics of renal tubular necrosis induced by cephaloridine.

8. Nephron transport and renal tubular effects of cephaloridine in animals.

9. Nephrotoxicity associated with the use of cephaloridine.

10. Relative nephrotoxicity of cephalosporin antibiotics in an animal model.

1. [Experimental studies on the renal tolerance of cefuroxime (author's transl)].

2. Effect of cefamandole nafate on the toxicity of tobramycin.

3. Tobramycin nephrotoxicity: failure of cefotaxime to potentiate renal toxicity.

4. [Nephrotoxicity of cefsulodin: experimental studies in animals (author's transl)].