Literature DB >> 11841870

Pyrrolo[1,2-f]phenanthridines and related non-rigid analogues as antiviral agents.

Anna Maria Almerico1, Francesco Mingoia, Patrizia Diana, Paola Barraja, Alessandra Montalbano, Antonino Lauria, Roberta Loddo, Laura Sanna, Donatella Delpiano, Maria Giovanna Setzu, Chiara Musiu.   

Abstract

The pyrrolo[1,2-f]phenanthridines 8-22 and the corresponding non-rigid analogues 23-41 were synthesised and their ability to inhibit the replication of HIV-1 was tested. Only the polycyclic derivatives 10, 11, and 13 showed a weak anti-HIV activity, whereas several pyrrolo-phenanthridines (8, 10, 16-18) were found to stimulate the multiplication of MT-4 cells at low concentrations. Derivative 10 demonstrated to possess the unique property of stimulating the multiplication of lymphocytes joined to HIV inhibition.

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Year:  2002        PMID： 11841870     DOI： 10.1016/s0223-5234(01)01289-2

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  4 in total

1.  Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and RDDP functions.

Authors:  Angela Corona; Valentina Onnis; Alessandro Deplano; Giulia Bianco; Monica Demurtas; Simona Distinto; Yung-Chi Cheng; Stefano Alcaro; Francesca Esposito; Enzo Tramontano
Journal:  Pathog Dis       Date:  2017-08-31       Impact factor: 3.166

2.  Dual vicinal functionalisation of heterocycles via an interrupted Pummerer coupling/[3,3]-sigmatropic rearrangement cascade.

Authors:  Mindaugas Šiaučiulis; Selma Sapmaz; Alexander P Pulis; David J Procter
Journal:  Chem Sci       Date:  2017-11-17       Impact factor: 9.825

Review 3.  Bioactive pyrrole-based compounds with target selectivity.

Authors:  Giovanna Li Petri; Virginia Spanò; Roberto Spatola; Ralph Holl; Maria Valeria Raimondi; Paola Barraja; Alessandra Montalbano
Journal:  Eur J Med Chem       Date:  2020-08-29       Impact factor: 6.514

4.  Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types.

Authors:  Virginia Spanò; Roberta Rocca; Marilia Barreca; Daniele Giallombardo; Alessandra Montalbano; Anna Carbone; Maria Valeria Raimondi; Eugenio Gaudio; Roberta Bortolozzi; Ruoli Bai; Pierfrancesco Tassone; Stefano Alcaro; Ernest Hamel; Giampietro Viola; Francesco Bertoni; Paola Barraja
Journal:  J Med Chem       Date:  2020-10-11       Impact factor: 7.446
  4 in total

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