Literature DB >> 11841602

Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients.

Egemen Savaskan1, Gianfranco Olivieri, Fides Meier, Lena Brydon, Ralf Jockers, Rivka Ravid, Anna Wirz-Justice, Franz Müller-Spahn.   

Abstract

The pineal secretory product melatonin has, in addition to regulating retinal, circadian and vascular functions, neuroprotective effects. Blood melatonin levels are often decreased in Alzheimer's disease (AD), a progressively disabling neurodegenerative disorder. In this study we provide the first immunohistochemical evidence for the localization of melatonin 1a-receptor (MT(1)) in aged human hippocampus and a comparison of AD cases. MT(1) was localized to pyramidal neurons in the hippocampal cornu ammonis (CA)1-4 subfields. There was a distinct increase in staining intensity in all AD cases indicating an up-regulation of the receptor, possibly as a compensatory response to impaired melatonin levels in order to augment melatonin's neuroprotective effects.

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Year:  2002        PMID： 11841602     DOI： 10.1034/j.1600-079x.2002.00841.x

Source DB:  PubMed          Journal:  J Pineal Res        ISSN： 0742-3098            Impact factor:   13.007


  32 in total

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7.  Drug- and region-specific effects of protracted antidepressant and cocaine treatment on the content of melatonin MT(1) and MT(2) receptor mRNA in the mouse brain.

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Journal:  Behav Brain Res       Date:  2018-01-31       Impact factor: 3.332

9.  Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors.

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