[Membrane and immunological aspects of perinatal nervous system disorders in newborns].

Results of clinical, biochemical, and immunological studies in 157 full-term newborns with perinatal hypoxic damage to the nervous system are analyzed. Activation of lipid peroxidation processes in platelet membranes (increased levels of dienic conjugates and Schiff bases), activation of endogenous phospholipases and lysosomal enzymes (cathepsin D and acid phosphatase) were revealed. Free-radical and enzymatic aggression led to stabilization of the lipid bilayer, which manifested by increase of enzymatic lysoforms and decrease in the total phospholipid content of membranes. Study of lymphocyte subpopulations by means of monoclonal antibodies and measurements of immunoglobulin concentrations showed that perinatal hypoxia impaired the formation of immune status. Acute hypoxia promoted the formation of transitory "stress immunodeficiency", while chronic hypoxia induced more stubborn immune disorders.