| Literature DB >> 11840323 |
Abstract
Helix-loop-helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development.Mesh：
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Year: 2001 PMID： 11840323 DOI： 10.1038/sj.onc.1205091
Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867