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Literature DB >> 11840304

Role of apoE/Abeta interactions in Alzheimer's disease: insights from transgenic mouse models.

R P Brendza¹, K R Bales, S M Paul, D M Holtzman.

Abstract

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2002 PMID： 11840304 DOI： 10.1038/sj.mp.4001006

Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 15.992

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12 in total

1. Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.

Authors: Irfan Y Tamboli; Esther Barth; Leonie Christian; Martin Siepmann; Sathish Kumar; Sandesh Singh; Karen Tolksdorf; Michael T Heneka; Dieter Lütjohann; Patrick Wunderlich; Jochen Walter
Journal: J Biol Chem Date: 2010-09-28 Impact factor: 5.157

Review 2. Recent rodent models for Alzheimer's disease: clinical implications and basic research.

Authors: Nady Braidy; Pablo Muñoz; Adrian G Palacios; Gloria Castellano-Gonzalez; Nibaldo C Inestrosa; Roger S Chung; Perminder Sachdev; Gilles J Guillemin
Journal: J Neural Transm (Vienna) Date: 2011-11-16 Impact factor: 3.575

3. Excessive/Aberrant and Maladaptive Synaptic Plasticity: A Hypothesis for the Pathogenesis of Alzheimer's Disease.

Authors: Shigeki Kawabata
Journal: Front Aging Neurosci Date: 2022-07-05 Impact factor: 5.702

4. Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits.

Authors: Haim Belinson; Dimitri Lev; Eliezer Masliah; Daniel M Michaelson
Journal: J Neurosci Date: 2008-04-30 Impact factor: 6.167

5. APOE2 enhances neuroprotection against Alzheimer's disease through multiple molecular mechanisms.

Authors: C Conejero-Goldberg; J J Gomar; T Bobes-Bascaran; T M Hyde; J E Kleinman; M M Herman; S Chen; P Davies; T E Goldberg
Journal: Mol Psychiatry Date: 2014-02-04 Impact factor: 15.992

6. A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade.

Authors: Iftach Dolev; Daniel M Michaelson
Journal: Proc Natl Acad Sci U S A Date: 2004-09-13 Impact factor: 11.205

Role of apoE/Abeta interactions in Alzheimer's disease: insights from transgenic mouse models.

1. Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.

Review 2. Recent rodent models for Alzheimer's disease: clinical implications and basic research.

3. Excessive/Aberrant and Maladaptive Synaptic Plasticity: A Hypothesis for the Pathogenesis of Alzheimer's Disease.

4. Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits.

5. APOE2 enhances neuroprotection against Alzheimer's disease through multiple molecular mechanisms.

6. A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade.

7. Genetically altering Abeta distribution from the brain to the vasculature ameliorates tau pathology.

8. GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity.

9. Modeling Alzheimer's disease: from past to future.

10. Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice.