Literature DB >> 11840164

c-FLIP efficiently rescues TRAF-2-/- cells from TNF-induced apoptosis.

C Guiet1, E Silvestri, E De Smaele, G Franzoso, P Vito.   

Abstract

For the past 20 years, it has been known that preparations of Tumor Necrosis Factor alpha (TNF) fail to induce apoptosis due to cytoprotective responses that render cells resistant to its cytotoxic activity. Here we show that TRAF-2-/- embryonic fibroblasts express reduced levels of the anti-apoptotic molecule c-FLIP due to extensive degradation of the protein. Reconstitution of TRAF-2-/- EF with c-FLIP is sufficient for resistance to TNF toxicity. Our results strengthen the role of c-FLIP in protecting cells from the cytotoxic effect of TNF and have implication for the treatment of inflammatory and proliferative disorders.

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Year:  2002        PMID： 11840164     DOI： 10.1038/sj.cdd.4400947

Source DB:  PubMed          Journal:  Cell Death Differ        ISSN： 1350-9047            Impact factor:   15.828


  21 in total

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3.  Tumor necrosis factor (TNF) receptor-associated factor 7 is required for TNFα-induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein.

Authors:  Ivan Scudiero; Tiziana Zotti; Angela Ferravante; Mariangela Vessichelli; Carla Reale; Maria C Masone; Antonio Leonardi; Pasquale Vito; Romania Stilo
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4.  Decreasing TNF-alpha results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis.

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5.  NF-κB Essential Modulator (NEMO) Is Critical for Thyroid Function.

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Review 6.  Cellular FLICE-inhibitory protein: an attractive therapeutic target?

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Journal:  Expert Opin Ther Targets       Date:  2003-08       Impact factor: 6.902

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Authors:  James E Vince; Delara Pantaki; Rebecca Feltham; Peter D Mace; Stephanie M Cordier; Anna C Schmukle; Angelina J Davidson; Bernard A Callus; Wendy Wei-Lynn Wong; Ian E Gentle; Holly Carter; Erinna F Lee; Henning Walczak; Catherine L Day; David L Vaux; John Silke
Journal:  J Biol Chem       Date:  2009-12-18       Impact factor: 5.157

8.  Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis.

Authors:  Colin Rae; Susana Langa; Steven J Tucker; David J MacEwan
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9.  In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.

Authors:  D M Moujalled; W D Cook; J M Lluis; N R Khan; A U Ahmed; B A Callus; D L Vaux
Journal:  Cell Death Differ       Date:  2011-11-18       Impact factor: 15.828

10.  Neuroepithelial transforming gene 1 (Net1) binds to caspase activation and recruitment domain (CARD)- and membrane-associated guanylate kinase-like domain-containing (CARMA) proteins and regulates nuclear factor κB activation.

Authors:  Mariangela Vessichelli; Angela Ferravante; Tiziana Zotti; Carla Reale; Ivan Scudiero; Gianluca Picariello; Pasquale Vito; Romania Stilo
Journal:  J Biol Chem       Date:  2012-02-16       Impact factor: 5.157
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