BACKGROUND: Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI) in infants throughout most of the world, but little is known about RSV infection in Africa where LRTI are among the leading causes of infant and childhood death. METHODS: The study took place in a rural district hospital in southern Mozambique between October, 1998, and May, 2000. From all children (n = 5635) <1 year of age presenting to an outpatient department with cough or nasal secretion and all children (n = 1307) <5 years of age admitted to hospital with a LRTI, a nasopharyngeal aspirate was collected and tested for RSV by enzyme-linked immunosorbent assay (Abbott). RESULTS: RSV infection was found in 8.6% of study infants in the outpatient department and 10.6% of admitted children with LRTI. Cases presented in predictable yearly outbreaks during the warm and rainy season. Lower respiratory tract involvement was frequent (59.7%). Cough, chest indrawing and increased respiratory rate were all independently related to RSV infection. Wheezing was infrequent. Bacterial coinfection (4.6%) and the case-fatality rate (3.4%) were low. CONCLUSIONS: There is a substantial burden of disease attributable to RSV infection in this rural African setting, with the highest incidence and severity occurring in young infants.
BACKGROUND:Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI) in infants throughout most of the world, but little is known about RSV infection in Africa where LRTI are among the leading causes of infant and childhood death. METHODS: The study took place in a rural district hospital in southern Mozambique between October, 1998, and May, 2000. From all children (n = 5635) <1 year of age presenting to an outpatient department with cough or nasal secretion and all children (n = 1307) <5 years of age admitted to hospital with a LRTI, a nasopharyngeal aspirate was collected and tested for RSV by enzyme-linked immunosorbent assay (Abbott). RESULTS:RSV infection was found in 8.6% of study infants in the outpatient department and 10.6% of admitted children with LRTI. Cases presented in predictable yearly outbreaks during the warm and rainy season. Lower respiratory tract involvement was frequent (59.7%). Cough, chest indrawing and increased respiratory rate were all independently related to RSV infection. Wheezing was infrequent. Bacterial coinfection (4.6%) and the case-fatality rate (3.4%) were low. CONCLUSIONS: There is a substantial burden of disease attributable to RSV infection in this rural African setting, with the highest incidence and severity occurring in young infants.
Authors: James A Berkley; Patrick Munywoki; Mwanajuma Ngama; Sidi Kazungu; John Abwao; Anne Bett; Ria Lassauniére; Tina Kresfelder; Patricia A Cane; Marietjie Venter; J Anthony G Scott; D James Nokes Journal: JAMA Date: 2010-05-26 Impact factor: 56.272
Authors: Paul D Scott; Rachel Ochola; Mwanajuma Ngama; Emelda A Okiro; D James Nokes; Graham F Medley; Patricia A Cane Journal: J Infect Dis Date: 2005-11-17 Impact factor: 5.226
Authors: Núria Díez-Padrisa; Quique Bassat; Sonia Machevo; Llorenç Quintó; Luis Morais; Tacilta Nhampossa; Cristina O'Callaghan-Gordo; Antoni Torres; Pedro L Alonso; Anna Roca Journal: PLoS One Date: 2010-10-14 Impact factor: 3.240
Authors: D James Nokes; Mwanajuma Ngama; Anne Bett; John Abwao; Patrick Munywoki; Mike English; J Anthony G Scott; Patricia A Cane; Graham F Medley Journal: Clin Infect Dis Date: 2009-11-01 Impact factor: 9.079
Authors: S B Omer; A Sutanto; H Sarwo; M Linehan; I G G Djelantik; D Mercer; V Moniaga; L H Moulton; A Widjaya; P Muljati; B D Gessner; M C Steinhoff Journal: Epidemiol Infect Date: 2008-01-04 Impact factor: 2.451
Authors: Emelda A Okiro; Mwanajuma Ngama; Ann Bett; Patricia A Cane; Graham F Medley; D James Nokes Journal: Trop Med Int Health Date: 2008-05-08 Impact factor: 2.622
Authors: Rachel Ochola; Charles Sande; Gregory Fegan; Paul D Scott; Graham F Medley; Patricia A Cane; D James Nokes Journal: PLoS One Date: 2009-12-02 Impact factor: 3.240