| Literature DB >> 11839856 |
Rayomand Press1, V Ozenci, M Kouwenhoven, H Link.
Abstract
The T(H)1 vs non-T(H)1 cytokine balance in Guillain-Barré syndrome (GBS) is unknown. Using enzyme-linked immunospot (ELISPOT) assays, we observed elevated numbers of interleukin (IL)-6 and IL-10-secreting blood mononuclear cells (BMNC) during the acute phase in untreated patients, and low levels of tumor necrosis factor alpha-secreting BMNC in the recovery phase of GBS. Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-T(H)1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS.Entities:
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Year: 2002 PMID: 11839856 DOI: 10.1212/wnl.58.3.476
Source DB: PubMed Journal: Neurology ISSN: 0028-3878 Impact factor: 9.910