Literature DB >> 11839445

Application of a factorial design to the study of specific parameters of a Carbopol ETD 2020 gel. Part I. Viscoelastic parameters.

M D Contreras1, R Sánchez.   

Abstract

This work studies the application of a 2(3) factorial design to a cosmetic gel with the aim of simplifying the analysis of the influence of the concentration of Carbopol ETD 2020 (cb), of ethanol (et) and of glycerin (gl) on the viscoelastic parameters: equilibrium modulus (Gn), critical molecular weight (Mc), degree of structuring (logG'/lognu) and viscous modulus (G"). We have obtained high linear polynomial correlations among the components and the response factors determined. The results obtained evidence the usefulness of this type of technique in detecting interactions among the components that would be difficult to foresee otherwise. Mc, logG'/lognu and G" depend on the interaction cb-et. Gn depends on the interaction of cb-et-gl. That is, an increase in gl can increase or decrease the elasticity (Gn) of the gels, depending on the concentrations of cb and et.

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Year:  2002        PMID: 11839445     DOI: 10.1016/s0378-5173(01)00953-x

Source DB:  PubMed          Journal:  Int J Pharm        ISSN: 0378-5173            Impact factor:   5.875


  2 in total

1.  Development of novel nonaqueous ethylcellulose gel matrices: rheological and mechanical characterization.

Authors:  P W S Heng; L W Chan; K T Chow
Journal:  Pharm Res       Date:  2005-04-07       Impact factor: 4.200

2.  Rheological evaluation of silicon/carbopol hydrophilic gel systems as a vehicle for delivery of water insoluble drugs.

Authors:  Giulia Bonacucina; Marco Cespi; Monica Misici-Falzi; Giovanni F Palmieri
Journal:  AAPS J       Date:  2008-02-05       Impact factor: 4.009

  2 in total

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