OBJECTIVE: To determine if there are significant differences in the temporal organization of rapid eye movement (REM) sleep microarchitecture between healthy controls and outpatients with major depressive disorder (MDD). METHODS: Forty age-matched subjects, 20 men and 20 women, half with MDD, were selected from an archive of sleep electroencephalography (EEG) data collected under identical conditions. Each participant spent 2 consecutive nights in the Sleep Study Unit of the University of Texas Southwestern Medical Center at Dallas, the first of which served as adaptation. The average amplitude in each of 5 conventional EEG frequency bands was computed for each REM period across the second night. Data were then coded for group and sex. RESULTS: Aside from REM latency, none of the key sleep macroarchitectural variables differentiated MDD patients from controls. REM latency was longest in men with MDD. Sleep microarchitecture, however, did show a number of between-group differences. In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. Group x sex interactions were also obtained for theta and alpha. Beta activity showed a unique temporal profile in each group, supported by a significant REM period x group x sex interaction. In addition, the temporal change in theta amplitude across REM periods was most striking in women with MDD. CONCLUSIONS: This study suggests that, like during non-REM sleep, EEG amplitude shows a systematic temporal change over successive REM sleep periods and also shows elements that are both disease- and sex-dependent.
OBJECTIVE: To determine if there are significant differences in the temporal organization of rapid eye movement (REM) sleep microarchitecture between healthy controls and outpatients with major depressive disorder (MDD). METHODS: Forty age-matched subjects, 20 men and 20 women, half with MDD, were selected from an archive of sleep electroencephalography (EEG) data collected under identical conditions. Each participant spent 2 consecutive nights in the Sleep Study Unit of the University of Texas Southwestern Medical Center at Dallas, the first of which served as adaptation. The average amplitude in each of 5 conventional EEG frequency bands was computed for each REM period across the second night. Data were then coded for group and sex. RESULTS: Aside from REM latency, none of the key sleep macroarchitectural variables differentiated MDDpatients from controls. REM latency was longest in men with MDD. Sleep microarchitecture, however, did show a number of between-group differences. In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. Group x sex interactions were also obtained for theta and alpha. Beta activity showed a unique temporal profile in each group, supported by a significant REM period x group x sex interaction. In addition, the temporal change in theta amplitude across REM periods was most striking in women with MDD. CONCLUSIONS: This study suggests that, like during non-REM sleep, EEG amplitude shows a systematic temporal change over successive REM sleep periods and also shows elements that are both disease- and sex-dependent.
Authors: T Hori; Y Sugita; E Koga; S Shirakawa; K Inoue; S Uchida; H Kuwahara; M Kousaka; T Kobayashi; Y Tsuji; M Terashima; K Fukuda; N Fukuda Journal: Psychiatry Clin Neurosci Date: 2001-06 Impact factor: 5.188
Authors: D J Kupfer; R F Ulrich; P A Coble; D B Jarrett; V Grochocinski; J Doman; G Matthews; A A Borbély Journal: Psychiatry Res Date: 1984-12 Impact factor: 3.222
Authors: A A Borbély; I Tobler; M Loepfe; D J Kupfer; R F Ulrich; V Grochocinski; J Doman; G Matthews Journal: Psychiatry Res Date: 1984-05 Impact factor: 3.222
Authors: D J Kupfer; R F Ulrich; P A Coble; D B Jarrett; V Grochocinski; J Doman; G Matthews; A A Borbély Journal: Psychiatry Res Date: 1984-12 Impact factor: 3.222
Authors: Michael R Dolsen; Philip Cheng; J Todd Arnedt; Leslie Swanson; Melynda D Casement; Hyang Sook Kim; Jennifer R Goldschmied; Robert F Hoffmann; Roseanne Armitage; Patricia J Deldin Journal: J Affect Disord Date: 2017-01-26 Impact factor: 4.839