| Literature DB >> 11836652 |
Maija Wessman1, Mikko Kallela, Mari A Kaunisto, Pia Marttila, Eric Sobel, Jaana Hartiala, Greg Oswell, Suzanne M Leal, Jeanette C Papp, Eija Hämäläinen, Petra Broas, Geoffrey Joslyn, Iiris Hovatta, Tero Hiekkalinna, Jaakko Kaprio, Jürg Ott, Rita M Cantor, John-Anker Zwart, Matti Ilmavirta, Hannele Havanka, Markus Färkkilä, Leena Peltonen, Aarno Palotie.
Abstract
Migraine is a complex neurovascular disorder with substantial evidence supporting a genetic contribution. Prior attempts to localize susceptibility loci for common forms of migraine have not produced conclusive evidence of linkage or association. To date, no genomewide screen for migraine has been published. We report results from a genomewide screen of 50 multigenerational, clinically well-defined Finnish families showing intergenerational transmission of migraine with aura (MA). The families were screened using 350 polymorphic microsatellite markers, with an average intermarker distance of 11 cM. Significant evidence of linkage was found between the MA phenotype and marker D4S1647 on 4q24. Using parametric two-point linkage analysis and assuming a dominant mode of inheritance, we found for this marker a maximum LOD score of 4.20 under locus homogeneity (P=.000006) or locus heterogeneity (P=.000011). Multipoint parametric (HLOD = 4.45; P=.0000058) and nonparametric (NPL(all) = 3.43; P=.0007) analyses support linkage in this region. Statistically significant linkage was not observed in any other chromosomal region.Entities:
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Year: 2002 PMID： 11836652 PMCID： PMC384944 DOI： 10.1086/339078
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025