| Literature DB >> 11836504 |
Hiroshi Hamada1, Chikara Meno, Daisuke Watanabe, Yukio Saijoh.
Abstract
The generation of morphological, such as left-right, asymmetry during development is an integral part of the establishment of a body plan. Until recently, the molecular basis of left-right asymmetry was a mystery, but studies indicate that Nodal and the Lefty proteins, transforming growth factor-beta-related molecules, have a central role in generating asymmetric signals. Although the initial mechanism of symmetry breaking remains unknown, developmental biologists are beginning to analyse the pathway that leads to left-right asymmetry establishment and maintenance.Mesh：
Substances：
Year: 2002 PMID： 11836504 DOI： 10.1038/nrg732
Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242