B Hilt1, T Qvenild, J Holme, K Svendsen, B Ulvestad. 1. Department of Occupational Medicine, University Hospital of Trondheim, N-7006 Trondheim, Norway. bjorn.hilt@medisin.ntnu.no
Abstract
OBJECTIVES: To see if there is any change in blood concentrations of interleukin-6 (IL-6) and fibrinogen during a working shift in tunnel construction workers. METHODS: 12 Tunnel construction workers were followed up during a 24 hours period after returning from a 9 day work free period. The first blood sample was taken on Monday afternoon before starting the shift. Another was taken around midnight after 8 hours of work, and another the next afternoon after about 12 hours of rest. Exposure to respirable dust was measured by personal samplers. RESULTS: The exposure of the workers to respirable dust, in terms of an 8 hour time weighted average, varied between 0.3 and 1.9 mg/m(3). For IL-6, there was an increase in the median serum concentration from 1.14 ng/l before starting the shift to 4.86 ng/l after 8 hours of work (p=0.002). For fibrinogen, there was an increase in the median concentration from 3.40 g/l before entering the shift to 3.70 g/l 24 hours later (p=0.044). There was a positive correlation between values of IL-6 at the end of the working shift and the fibrinogen concentrations the next afternoon (Pearson's R=0.73, p=0.007). The observed increase in IL-6 was significant for both smokers and non-smokers. CONCLUSION: The study shows an increase in both IL-6 and fibrinogen concentrations during a working shift for both smoking and non-smoking tunnel construction workers.
OBJECTIVES: To see if there is any change in blood concentrations of interleukin-6 (IL-6) and fibrinogen during a working shift in tunnel construction workers. METHODS: 12 Tunnel construction workers were followed up during a 24 hours period after returning from a 9 day work free period. The first blood sample was taken on Monday afternoon before starting the shift. Another was taken around midnight after 8 hours of work, and another the next afternoon after about 12 hours of rest. Exposure to respirable dust was measured by personal samplers. RESULTS: The exposure of the workers to respirable dust, in terms of an 8 hour time weighted average, varied between 0.3 and 1.9 mg/m(3). For IL-6, there was an increase in the median serum concentration from 1.14 ng/l before starting the shift to 4.86 ng/l after 8 hours of work (p=0.002). For fibrinogen, there was an increase in the median concentration from 3.40 g/l before entering the shift to 3.70 g/l 24 hours later (p=0.044). There was a positive correlation between values of IL-6 at the end of the working shift and the fibrinogen concentrations the next afternoon (Pearson's R=0.73, p=0.007). The observed increase in IL-6 was significant for both smokers and non-smokers. CONCLUSION: The study shows an increase in both IL-6 and fibrinogen concentrations during a working shift for both smoking and non-smoking tunnel construction workers.
Authors: A N Vgontzas; D A Papanicolaou; E O Bixler; A Lotsikas; K Zachman; A Kales; P Prolo; M L Wong; J Licinio; P W Gold; R C Hermida; G Mastorakos; G P Chrousos Journal: J Clin Endocrinol Metab Date: 1999-08 Impact factor: 5.958
Authors: Regina Rückerl; Sonja Greven; Petter Ljungman; Pasi Aalto; Charalambos Antoniades; Tom Bellander; Niklas Berglind; Christina Chrysohoou; Francesco Forastiere; Bénédicte Jacquemin; Stephanie von Klot; Wolfgang Koenig; Helmut Küchenhoff; Timo Lanki; Juha Pekkanen; Carlo A Perucci; Alexandra Schneider; Jordi Sunyer; Annette Peters Journal: Environ Health Perspect Date: 2007-07 Impact factor: 9.031