Literature DB >> 11836114

3,5-dibenzoyl-1,4-dihydropyridines: synthesis and MDR reversal in tumor cells.

Masami Kawase1, Anamik Shah, Harsukh Gaveriya, Noboru Motohashi, Hiroshi Sakagami, Andreas Varga, Joseph Molnár.   

Abstract

Fifteen 4-phenyl-3,5-dibenzoyl-1,4-dihydropyridines (BzDHPs) (1-15) substituted at the 4-phenyl ring were synthesized and compared to their cytotoxic activity and multidrug resistance (MDR)-reversing activity in in vitro assay systems. Among them, 2-CF3 (5) (IC50=8.7 microM), 2-Cl (11) (IC50=7.0 microM) and 3-Cl (12) (IC50=7.0 microM) derivatives showed the highest cytotoxic activity against human oral squamous carcinoma (HSC-2) cells. The activity of P-glycoprotein (Pgp) response for MDR in tumor cells was reduced by some of derivatives (3, 4, 8, 12), verapamil (VP) and nifedipine (NP). These data suggest that 3,5-dibenzoyl-4-(3-chlorophenyl)-1,4-dihydro-2,6-dimethylpyridine (12) can be recommended as a new drug candidate for MDR cancer treatment.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11836114     DOI： 10.1016/s0968-0896(01)00363-7

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  12 in total

1.  Bio-activation of 4-alkyl analogs of 1,4-dihydropyridine mediated by cytochrome P450 enzymes.

Authors:  Xiao-Xi Li; Xiaoqian Zhang; Qing-Chuan Zheng; Yong Wang
Journal:  J Biol Inorg Chem       Date:  2015-03-18       Impact factor: 3.358

2.  5-Oxo-hexahydroquinoline and 5-oxo-tetrahydrocyclopentapyridine derivatives as promising antiproliferative agents with potential apoptosis-inducing capacity.

Authors:  Sara Ranjbar; Mehdi Khoshneviszadeh; Marjan Tavakkoli; Ramin Miri; Najmeh Edraki; Omidreza Firuzi
Journal:  Mol Divers       Date:  2021-10-20       Impact factor: 2.943

3.  3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility.

Authors:  Simona Saponara; Masami Kawase; Anamik Shah; Noboru Motohashi; Joseph Molnar; Katalin Ugocsai; Giampietro Sgaragli; Fabio Fusi
Journal:  Br J Pharmacol       Date:  2004-01-12       Impact factor: 8.739

4.  1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: a novel series of highly potent revertants of P-glycoprotein associated multidrug resistance.

Authors:  Umashankar Das; Joseph Molnár; Zoltán Baráth; Zsuzsanna Bata; Jonathan R Dimmock
Journal:  Bioorg Med Chem Lett       Date:  2008-05-16       Impact factor: 2.823

5.  ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal.

Authors:  Cheol-Hee Choi
Journal:  Cancer Cell Int       Date:  2005-10-04       Impact factor: 5.722

6.  Assessment of the Cytotoxic Effect of a Series of 1,4-Dihydropyridine Derivatives Against Human Cancer Cells.

Authors:  Nima Razzaghi-Asl; Ramin Miri; Omidreza Firuzi
Journal:  Iran J Pharm Res       Date:  2016       Impact factor: 1.696

7.  Design, Synthesis and Anti-Tubercular Activity of Novel 1, 4-Dihydropyrine-3, 5-Dicarboxamide Containing 4(5)-Chloro-2-Ethyl- 5(4)-Imidazolyl Moiety.

Authors:  Maryam Iman; Asghar Davood; Mahboubeh Lotfinia; Golnoush Dehqani; Soroush Sardari; Parisa Azerang; Mohsen Amini
Journal:  Iran J Pharm Res       Date:  2016       Impact factor: 1.696

8.  Mo@GAA-Fe3O4 MNPs: a highly efficient and environmentally friendly heterogeneous magnetic nanocatalyst for the synthesis of polyhydroquinoline derivatives.

Authors:  Mehraneh Aghaei-Hashjin; Asieh Yahyazadeh; Esmayeel Abbaspour-Gilandeh
Journal:  RSC Adv       Date:  2021-03-11       Impact factor: 3.361

9.  Oxidative Aromatization, Cytotoxic Activity Evaluation and Conformational Study of Novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione Derivatives.

Authors:  Radineh Motamedi; Abbas Shafiee; Mohammad Reza Rezai; Omidreza Firuzi; Najmeh Edraki; Ramin Miri
Journal:  Iran J Pharm Res       Date:  2014       Impact factor: 1.696

10.  Design, Synthesis and Evaluation of Antitubercular Activity of Novel Dihydropyridine Containing Imidazolyl Substituent.

Authors:  Maryam Iman; Asghar Davood; Golnoush Dehqani; Mahboubeh Lotfinia; Soroush Sardari; Parisa Azerang; Mohsen Amini
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.