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Literature DB >> 11835050

Limits to lifespan.

Abstract

It has long-been accepted that normal somatic cells have intrinsic mechanisms that limit their proliferative lifespan. Recent work has now challenged this view by demonstrating that extrinsic factors might be determining proliferative potential.

Mesh：

Substances：
Telomerase

Year: 2002 PMID： 11835050 DOI： 10.1038/ncb0202-e25

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

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Cited

19 in total

Review 1. When cells get stressed: an integrative view of cellular senescence.

Authors: Ittai Ben-Porath; Robert A Weinberg
Journal: J Clin Invest Date: 2004-01 Impact factor: 14.808

Review 2. Evidence-based roads to the promotion of health in old age.

Authors: P Ljubuncic; A Globerson; A Z Reznick
Journal: J Nutr Health Aging Date: 2008-02 Impact factor: 4.075

Review 3. Senescence regulation by the p53 protein family.

Authors: Yingjuan Qian; Xinbin Chen
Journal: Methods Mol Biol Date: 2013

4. The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7.

Authors: Trisha M Wise-Draper; Hillary V Allen; Megan N Thobe; Elizabeth E Jones; Kristen B Habash; Karl Münger; Susanne I Wells
Journal: J Virol Date: 2005-11 Impact factor: 5.103

5. Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program.

Authors: Dmitri G Negorev; Olga V Vladimirova; Andrew V Kossenkov; Elena V Nikonova; Renee M Demarest; Anthony J Capobianco; Michael K Showe; Frank J Rauscher; Louise C Showe; Gerd G Maul
Journal: Cancer Res Date: 2010-11-30 Impact factor: 12.701

Limits to lifespan.

Review 1. When cells get stressed: an integrative view of cellular senescence.

Review 2. Evidence-based roads to the promotion of health in old age.

Review 3. Senescence regulation by the p53 protein family.

4. The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7.

5. Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program.

6. Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).

7. Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells.

Review 8. Melanomagenesis: overcoming the barrier of melanocyte senescence.

9. Knockout of Ku86 accelerates cellular senescence induced by high NaCl.

10. Endothelial progenitor cells dysfunction and senescence: contribution to oxidative stress.