Jie Fu1, Xun Sun, Zhi-Rong Zhang. 1. West China School of Pharmacy, Sichuan University.Chengdu, 610041, China.
Abstract
AIM: To study the bioadhesive property of carbomer934 in dog alimentary tract. METHODS: Carbomer934 and ethylcellulose were radiolabelled with technetium-99m; and Gastrointestinal emptying rate of materials was measured using the technique of gamma scintigraphy. RESULTS: After oral administration,the maximum intestinal radioactivity of non-bioadhesive granules and bioadhesive granules were observed in the second hour and the sixth hour respectively. Constants of stomach emptying rate of nonadhesive granules,bioadhesive granules I and bioadhesive granules II were 0.774 h(-1), 0.265 h(-1) and 0.321 h(-1) respectively on the base of gastric residual amount. Compared to nonadhesive material (ethylcellulose), the migration rate of adhesive material(carbomer934) was remarkably slower in dog alimentary canal. CONCLUSION: It is concluded that, in the dog, interactions between gastrointestinal mucus layer and adhesive material or nonadhesive material were significantly different. Carbomer934 had stronger in vivo bioadhesive property than ethylcellulose.
AIM: To study the bioadhesive property of carbomer934 in dog alimentary tract. METHODS: Carbomer934 and ethylcellulose were radiolabelled with technetium-99m; and Gastrointestinal emptying rate of materials was measured using the technique of gamma scintigraphy. RESULTS: After oral administration,the maximum intestinal radioactivity of non-bioadhesive granules and bioadhesive granules were observed in the second hour and the sixth hour respectively. Constants of stomach emptying rate of nonadhesive granules,bioadhesive granules I and bioadhesive granules II were 0.774 h(-1), 0.265 h(-1) and 0.321 h(-1) respectively on the base of gastric residual amount. Compared to nonadhesive material (ethylcellulose), the migration rate of adhesive material(carbomer934) was remarkably slower in dog alimentary canal. CONCLUSION: It is concluded that, in the dog, interactions between gastrointestinal mucus layer and adhesive material or nonadhesive material were significantly different. Carbomer934 had stronger in vivo bioadhesive property than ethylcellulose.
Authors: R G Riley; J D Smart; J Tsibouklis; P W Dettmar; F Hampson; J A Davis; G Kelly; W R Wilber Journal: Int J Pharm Date: 2001-04-17 Impact factor: 5.875
Authors: M Muramatsu; K Kanada; A Nishida; K Ouchi; N Saito; M Yoshida; A Shimoaka; T Ozeki; H Yuasa; Y Kanaya Journal: Int J Pharm Date: 2000-04-10 Impact factor: 5.875