Literature DB >> 11832226

A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.

Xu Tao1, Anne E West, Wen G Chen, Gabriel Corfas, Michael E Greenberg.   

Abstract

Transcription of the brain-derived neurotrophic factor (BDNF) gene is regulated in a calcium- and neuron-selective manner; however, the mechanisms that underlie this selectivity are not known. We have characterized a new calcium-response element, CaRE1, that is required for activity-dependent transcription of BDNF exon III and have cloned a transcription factor, CaRF, that activates transcription from BDNF promoter III in a CaRE1-dependent manner. The transcriptional activity of CaRF is regulated in a calcium- and neuron-selective manner, suggesting that CaRF may confer selectivity upon the activity-dependent induction of BDNF exon III expression.

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Year:  2002        PMID： 11832226     DOI： 10.1016/s0896-6273(01)00561-x

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  130 in total

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