Literature DB >> 11832221

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization.

Raphael Kopan1, Alison Goate.   

Abstract

The Notch signaling pathway plays a role in cell fate specification in many metazoans. A critical aspect of Notch activation involves proteolysis of the Notch receptor. This cleavage event requires Presenilin as a component of a large multiprotein complex, gamma-secretase. This complex mediates a similar cleavage event of the beta-amyloid precursor protein (APP). The transmembrane protein Nicastrin has been found to associate with Presenilin, Notch, and APP. Recent biochemical and genetic studies have focused on elucidating the function of this protein.

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Year:  2002        PMID： 11832221     DOI： 10.1016/s0896-6273(02)00585-8

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  20 in total

1.  Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.

Authors:  Dieter Edbauer; Edith Winkler; Christian Haass; Harald Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-04       Impact factor: 11.205

2.  Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.

Authors:  Richard Rozmahel; Howard T J Mount; Fusheng Chen; Van Nguyen; Jean Huang; Serap Erdebil; Jennifer Liauw; Gang Yu; Hiroshe Hasegawa; YongJun Gu; You-Qiang Song; Stephen D Schmidt; Ralph A Nixon; Paul M Mathews; Catherine Bergeron; Paul Fraser; David Westaway; Peter St George-Hyslop
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-18       Impact factor: 11.205

3.  Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability.

Authors:  Kevin C Kanning; Mark Hudson; Paul S Amieux; Jesse C Wiley; Mark Bothwell; Leslayann C Schecterson
Journal:  J Neurosci       Date:  2003-07-02       Impact factor: 6.167

4.  Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production.

Authors:  Kei Suga; Takami Tomiyama; Hiroshi Mori; Kimio Akagawa
Journal:  Biochem J       Date:  2004-08-01       Impact factor: 3.857

5.  Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling.

Authors:  Gabriel Frampton; Monique Coufal; Huang Li; Jonathan Ramirez; Sharon DeMorrow
Journal:  Exp Cell Res       Date:  2010-03-25       Impact factor: 3.905

6.  PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.

Authors:  Stephen J Dearmond; Krystyna Bajsarowicz
Journal:  Mol Neurodegener       Date:  2010-01-21       Impact factor: 14.195

Review 7.  γ-Secretase and its modulators: Twenty years and beyond.

Authors:  Weiming Xia
Journal:  Neurosci Lett       Date:  2019-02-11       Impact factor: 3.046

8.  A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.

Authors:  Eric H Schroeter; Ma Xenia G Ilagan; Anne L Brunkan; Silva Hecimovic; Yue-ming Li; Min Xu; Huw D Lewis; Meera T Saxena; Bart De Strooper; Archie Coonrod; Taisuke Tomita; Takeshi Iwatsubo; Chad L Moore; Alison Goate; Michael S Wolfe; Mark Shearman; Raphael Kopan
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-17       Impact factor: 11.205

9.  Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein.

Authors:  Ting Yang; Dilyara Arslanova; Yongli Gu; Corinne Augelli-Szafran; Weiming Xia
Journal:  Mol Brain       Date:  2008-11-04       Impact factor: 4.041

Review 10.  Drosophila melanogaster as a model organism of brain diseases.

Authors:  Astrid Jeibmann; Werner Paulus
Journal:  Int J Mol Sci       Date:  2009-02-02       Impact factor: 6.208
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