| Literature DB >> 11832206 |
Ricky W Johnstone1, Astrid A Ruefli, Scott W Lowe.
Abstract
Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.Entities:
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Year: 2002 PMID： 11832206 DOI： 10.1016/s0092-8674(02)00625-6
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582