G Feng1, Y Tan. 1. Department of General Surgery, Railway General Hospital of Beijing, Beijing 100038, China.
Abstract
OBJECTIVE: To evaluate the relationship between the expression of MMP(2), type IV collagen, and invasion and metastasis of gastric cancer. METHODS: The expression of MMP(2) and Type IV collagen was observed by using immunohistochemistry technique. RESULTS: The MMP(2) expression clearly appeared in the poor-differentiated adenocarcinoma and tubular adenocarcinoma (85.7%, 77.7%). Type IV collagen destruction was observed simultaneously. MMP(2) was highly expressed in patients with cancer embolus in blood vessel and lymphatic vessel or with lymph node metastasis (83.3%, 86.7%). CONCLUSIONS: The high expression of MMP(2) was significantly associated with infiltration and metastasis of gastric cancer. The extracellular matrix, especially type IV collagen was destroyed in the cases of high expression of MMP(2). These results suggest that monitoring the level of MMP(2) expression may be an index for evaluation of prognosis.
OBJECTIVE: To evaluate the relationship between the expression of MMP(2), type IV collagen, and invasion and metastasis of gastric cancer. METHODS: The expression of MMP(2) and Type IV collagen was observed by using immunohistochemistry technique. RESULTS: The MMP(2) expression clearly appeared in the poor-differentiated adenocarcinoma and tubular adenocarcinoma (85.7%, 77.7%). Type IV collagen destruction was observed simultaneously. MMP(2) was highly expressed in patients with cancer embolus in blood vessel and lymphatic vessel or with lymph node metastasis (83.3%, 86.7%). CONCLUSIONS: The high expression of MMP(2) was significantly associated with infiltration and metastasis of gastric cancer. The extracellular matrix, especially type IV collagen was destroyed in the cases of high expression of MMP(2). These results suggest that monitoring the level of MMP(2) expression may be an index for evaluation of prognosis.