| Literature DB >> 11831887 |
Stacy W Remiszewski, Lidia C Sambucetti, Peter Atadja, Kenneth W Bair, Wendy D Cornell, Michael A Green, Kobporn Lulu Howell, Manfred Jung, Paul Kwon, Nancy Trogani, Heather Walker.
Abstract
Inhibitors of histone deacetylase (HDAC) have been shown to induce terminal differentiation of human tumor cell lines and to have antitumor effects in vivo. We have prepared analogues of suberoylanilide hydroxamic acid (SAHA) and trichostatin A and have evaluated them in a human HDAC enzyme inhibition assay, a p21(waf1) (p21) promoter assay, and in monolayer growth inhibition assays. One compound, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, was found to affect the growth of a panel of eight human tumor cell lines differentially.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11831887 DOI： 10.1021/jm015568c
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446