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Literature DB >> 11830352

Roles of the Werner syndrome protein in pathways required for maintenance of genome stability.

Abstract

Werners syndrome is a disease of premature aging where the patients appear much older than their chronological age. The gene codes for a protein that is a helicase and an exonuclease, and recently we have learned about some of its protein interactions. These interactions are being discussed as they shed light on the molecular pathways in which Werner protein participates. Insight into these pathways brings insight into the aging process.

Entities: Disease Species

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Year: 2002 PMID： 11830352 DOI： 10.1016/s0531-5565(01)00227-3

Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032

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Cited

17 in total

1. Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein.

Authors: Yongli Bai; John P Murnane
Journal: Hum Genet Date: 2003-06-25 Impact factor: 4.132

2. Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes.

Authors: Jennifer J Rahn; Megan P Lowery; Luis Della-Coletta; Gerald M Adair; Rodney S Nairn
Journal: Mech Ageing Dev Date: 2010-08-12 Impact factor: 5.432

3. Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone.

Authors: Noé Galván; Sophia Lim; Stephan Zmugg; Martyn T Smith; Luoping Zhang
Journal: Mutat Res Date: 2007-08-07 Impact factor: 2.433

4. Homologous recombination resolution defect in werner syndrome.

Authors: Yannick Saintigny; Kate Makienko; Cristina Swanson; Mary J Emond; Raymond J Monnat
Journal: Mol Cell Biol Date: 2002-10 Impact factor: 4.272

5. Werner syndrome protein limits MYC-induced cellular senescence.

Authors: Carla Grandori; Kou-Juey Wu; Paula Fernandez; Celine Ngouenet; Jonathan Grim; Bruce E Clurman; Michael J Moser; Junko Oshima; David W Russell; Karen Swisshelm; Scott Frank; Bruno Amati; Riccardo Dalla-Favera; Raymond J Monnat
Journal: Genes Dev Date: 2003-07-01 Impact factor: 11.361

6. WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork.

Authors: Sudha Sharma; Marit Otterlei; Joshua A Sommers; Henry C Driscoll; Grigory L Dianov; Hui-I Kao; Robert A Bambara; Robert M Brosh
Journal: Mol Biol Cell Date: 2003-12-02 Impact factor: 4.138

Roles of the Werner syndrome protein in pathways required for maintenance of genome stability.

1. Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein.

2. Depletion of Werner helicase results in mitotic hyperrecombination and pleiotropic homologous and nonhomologous recombination phenotypes.

3. Depletion of WRN enhances DNA damage in HeLa cells exposed to the benzene metabolite, hydroquinone.

4. Homologous recombination resolution defect in werner syndrome.

5. Werner syndrome protein limits MYC-induced cellular senescence.

6. WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork.

7. Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution.

8. Requirement of Rrm3 helicase for repair of spontaneous DNA lesions in cells lacking Srs2 or Sgs1 helicase.

9. Intrinsic ssDNA annealing activity in the C-terminal region of WRN.

10. Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion.