Literature DB >> 11830162

Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses.

H Ranjith W Dharmaratne1, N P Dhammika Nanayakkara, Ikhlas A Khan.   

Abstract

The kavalactone, 11-methoxy-5,6-dihydroyangonin, and eight previously reported analogs along with four other aromatic compounds were isolated from the root extracts of Piper methysticum (Kava Kava). Their structural elucidations were made by 1H and 13C NMR spectroscopic assignments using COSY, HMBC and HMQC experiments.

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Year:  2002        PMID： 11830162     DOI： 10.1016/s0031-9422(01)00443-5

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  24 in total

1.  Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth.

Authors:  Yaxiong Tang; Xuesen Li; Zhongbo Liu; Anne R Simoneau; Jun Xie; Xiaolin Zi
Journal:  Int J Cancer       Date:  2010-10-15       Impact factor: 7.396

2.  Bioactive Compounds from Medicinal Plants in Myanmar.

Authors:  Nwet Nwet Win; Hiroyuki Morita
Journal:  Prog Chem Org Nat Prod       Date:  2021

3.  Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes.

Authors:  Keanu D Pinner; Christina T K Wales; Rachel A Gristock; Hoa T Vo; Nadine So; Aaron T Jacobs
Journal:  Pharm Biol       Date:  2016-01-20       Impact factor: 3.503

4.  Estrogenic and serotonergic butenolides from the leaves of Piper hispidum Swingle (Piperaceae).

Authors:  Joanna L Michel; Yegao Chen; Hongjie Zhang; Yue Huang; Aleksej Krunic; Jimmy Orjala; Mario Veliz; Kapil K Soni; Djaja Doel Soejarto; Armando Caceres; Alice Perez; Gail B Mahady
Journal:  J Ethnopharmacol       Date:  2010-03-19       Impact factor: 4.360

5.  Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways.

Authors:  Ping Zhou; Shimon Gross; Ji-Hua Liu; Bo-Yang Yu; Ling-Ling Feng; Jan Nolta; Vijay Sharma; David Piwnica-Worms; Samuel X Qiu
Journal:  FASEB J       Date:  2010-08-09       Impact factor: 5.191

6.  Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice.

Authors:  Kennon M Garrett; Garo Basmadjian; Ikhlas A Khan; Brian T Schaneberg; Thomas W Seale
Journal:  Psychopharmacology (Berl)       Date:  2003-07-04       Impact factor: 4.530

7.  Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity.

Authors:  Ahmad Ali Shaik; David Lee Hermanson; Chengguo Xing
Journal:  Bioorg Med Chem Lett       Date:  2009-08-06       Impact factor: 2.823

8.  In vivo antitumor and antimetastatic effects of flavokawain B in 4T1 breast cancer cell-challenged mice.

Authors:  Nadiah Abu; Nurul Elyani Mohamed; Swee Keong Yeap; Kian Lam Lim; M Nadeem Akhtar; Aimi Jamil Zulfadli; Beh Boon Kee; Mohd Puad Abdullah; Abdul Rahman Omar; Noorjahan Banu Alitheen
Journal:  Drug Des Devel Ther       Date:  2015-03-06       Impact factor: 4.162

9.  A plant kavalactone desmethoxyyangonin prevents inflammation and fulminant hepatitis in mice.

Authors:  Tsui-Wei Chou; Jia-Hua Feng; Chi-Chang Huang; Ya-Wen Cheng; Shih-Chang Chien; Sheng-Yang Wang; Lie-Fen Shyur
Journal:  PLoS One       Date:  2013-10-15       Impact factor: 3.240

10.  The flavokawains: uprising medicinal chalcones.

Authors:  Nadiah Abu; Wan Yong Ho; Swee Keong Yeap; M Nadeem Akhtar; Mohd Puad Abdullah; Abdul Rahman Omar; Noorjahan Banu Alitheen
Journal:  Cancer Cell Int       Date:  2013-10-22       Impact factor: 5.722
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