Literature DB >> 11830150

Vernoguinosterol and vernoguinoside, trypanocidal stigmastane derivatives from Vernonia guineensis (Asteraceae).

Alembert T Tchinda1, Apollinaire Tsopmo, Pierre Tane, Johnson F Ayafor, Joseph D Connolly, Olov Sterner.   

Abstract

Two bitter stigmastane derivatives, vernoguinosterol (1) and vernoguinoside (2), have been isolated from the stem bark of Vernonia guineensis and their structures eludicated using spectroscopic methods. The new compounds exhibit trypanocidal activity.

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Year:  2002        PMID： 11830150     DOI： 10.1016/s0031-9422(01)00448-4

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  9 in total

1.  Antiplasmodial activity of sesquiterpene lactones and a sucrose ester from Vernonia guineensis Benth. (Asteraceae).

Authors:  Ngeh J Toyang; Michael A Krause; Rick M Fairhurst; Pierre Tane; Joseph Bryant; Rob Verpoorte
Journal:  J Ethnopharmacol       Date:  2013-03-27       Impact factor: 4.360

2.  In vivo antiprostate tumor potential of Vernonia guineensis Benth. (Asteraceae) tuber extract (VGDE) and the cytotoxicity of its major compound pentaisovaleryl sucrose.

Authors:  Ngeh J Toyang; Eugene N Ateh; Harry Davis; Pierre Tane; Luc B Sondengam; Joseph Bryant; Rob Verpoorte
Journal:  J Ethnopharmacol       Date:  2013-10-01       Impact factor: 4.360

3.  Cytotoxic sesquiterpene lactones from the leaves of Vernonia guineensis Benth. (Asteraceae).

Authors:  Ngeh J Toyang; Hippolyte K Wabo; Eugene N Ateh; Harry Davis; Pierre Tane; Luc B Sondengam; Joseph Bryant; Rob Verpoorte
Journal:  J Ethnopharmacol       Date:  2013-01-30       Impact factor: 4.360

4.  Cameroonian medicinal plants: pharmacology and derived natural products.

Authors:  Victor Kuete; Thomas Efferth
Journal:  Front Pharmacol       Date:  2010-10-25       Impact factor: 5.810

5.  In Vivo anti-trypanosomal activity of dichloromethane and methanol crude leaf extracts of Dovyalis abyssinica (Salicaceae) against Trypanosoma congolense.

Authors:  Belay Tadesse; Getachew Terefe; Nigatu Kebede; Workineh Shibeshi
Journal:  BMC Complement Altern Med       Date:  2015-08-14       Impact factor: 3.659

Review 6.  The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases.

Authors:  Peter Mubanga Cheuka; Godfrey Mayoka; Peggoty Mutai; Kelly Chibale
Journal:  Molecules       Date:  2016-12-31       Impact factor: 4.411

7.  Cytotoxic and antimicrobial activity of selected Cameroonian edible plants.

Authors:  Jean Paul Dzoyem; Santosh Kumar Guru; Constant Anatole Pieme; Victor Kuete; Akash Sharma; Inshad Ali Khan; Ajit Kumar Saxena; Ram Anuj Vishwakarma
Journal:  BMC Complement Altern Med       Date:  2013-04-08       Impact factor: 3.659

Review 8.  Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis.

Authors:  Conrad V Simoben; Fidele Ntie-Kang; Sergi H Akone; Wolfgang Sippl
Journal:  Nat Prod Bioprospect       Date:  2018-05-09

9.  Comparative molecular docking of antitrypanosomal natural products into multiple Trypanosoma brucei drug targets.

Authors:  Ifedayo V Ogungbe; William N Setzer
Journal:  Molecules       Date:  2009-04-14       Impact factor: 4.411
  9 in total

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