OBJECTIVE: To investigate the pathological and clinical effects of preoperative selective intra-arterial infusion chemotherapy on colorectal carcinoma. METHODS: 30 patients with colorectal carcinoma underwent selective regional arterial angiography by Seldinger's method followed by intra-arterial infusion chemotherapy. RESULTS: changes of karyopyknosis, karyorrhexis, coagulation and necrosis of cytoplasm in cancer cells around vascular vessels were found in all cases. Interstitial edema, invasion of inflammatory cells, fibroelastosis around cancer cells, proliferous intima, thrombus and inflammation of vessels were also found at the same sites. CONCLUSIONS: Histological changes are significant after preoperative selective intra-arterial infusion chemotherapy for colorectal carcinoma. This therapy can relieve symptoms.
OBJECTIVE: To investigate the pathological and clinical effects of preoperative selective intra-arterial infusion chemotherapy on colorectal carcinoma. METHODS: 30 patients with colorectal carcinoma underwent selective regional arterial angiography by Seldinger's method followed by intra-arterial infusion chemotherapy. RESULTS: changes of karyopyknosis, karyorrhexis, coagulation and necrosis of cytoplasm in cancer cells around vascular vessels were found in all cases. Interstitial edema, invasion of inflammatory cells, fibroelastosis around cancer cells, proliferous intima, thrombus and inflammation of vessels were also found at the same sites. CONCLUSIONS: Histological changes are significant after preoperative selective intra-arterial infusion chemotherapy for colorectal carcinoma. This therapy can relieve symptoms.