M Sun1, Y Liu, W Liu, G Deng, W Tang, Z Jiang. 1. Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730.
Abstract
OBJECTIVE: To study lactulose (lactulose, L) and mannitol (mannitol, M) ratio in urine following operation and investigate the correlation between severity of stress and L/M ratio. METHODS: 20 patients who had received operation were enrolled and each patient was evaluated by APACH II scores. L/M permeability study was performed before the operation and 5 and 10 days after the operation. The L and M concentration was analyzed by HPLC with pulsed electrochemical detection (HPLC-PED). The correlation between L/M ratio and the severity of surgical stress were related. RESULTS: The L/M ratio before the operation was (0.023 +/- 0.002), increased to (0.042 +/- 0.005) in the 5th post-operative day (P < 0.01), and then returned to (0.024 +/- 0.002) (P > 0.05) compared with pre-operation in the 10th Post-operation. A significant correlation between the severity of stress and the L/M ratio was observed (r = 0.762). CONCLUSIONS: The L/M ratio was increased 5 days after the operation and the L/M ratio was correlated with severity of operative stress.
OBJECTIVE: To study lactulose (lactulose, L) and mannitol (mannitol, M) ratio in urine following operation and investigate the correlation between severity of stress and L/M ratio. METHODS: 20 patients who had received operation were enrolled and each patient was evaluated by APACH II scores. L/M permeability study was performed before the operation and 5 and 10 days after the operation. The L and M concentration was analyzed by HPLC with pulsed electrochemical detection (HPLC-PED). The correlation between L/M ratio and the severity of surgical stress were related. RESULTS: The L/M ratio before the operation was (0.023 +/- 0.002), increased to (0.042 +/- 0.005) in the 5th post-operative day (P < 0.01), and then returned to (0.024 +/- 0.002) (P > 0.05) compared with pre-operation in the 10th Post-operation. A significant correlation between the severity of stress and the L/M ratio was observed (r = 0.762). CONCLUSIONS: The L/M ratio was increased 5 days after the operation and the L/M ratio was correlated with severity of operative stress.