Literature DB >> 1182941

Does the surface tension make the lung inherently unstable?

Y C Fung.   

Abstract

Many authors regard the human lung as a collection of 300 million bubbles independently connected by cylindrical tubes. Under surface tension such a model is inherently unstable in the sense that the small alveoli would empty into the large ones so that the lung would consist only of collapses and hyperinflated alveoli. It has been demonstrated that this basic model is wrong. My observation is based on the well-known fact that both sides of each interalveolar septum are exposed to ventilated air. When the topological relationship between the alveolar septa is properly taken into account, it can be shown that each interalveolar septum is a minimal surface and that there is no problem of inherent instability in the sense mentioned earlier. However, the lung structure is flimsy and can become unstable in the same sense that an airplane structure or an Atlas rocket can become unstable. The clarification of lung inflation and atelectasis can proceed in a rational manner when the confusion of an erroneous model is removed.

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Year:  1975        PMID: 1182941     DOI: 10.1161/01.res.37.4.497

Source DB:  PubMed          Journal:  Circ Res        ISSN: 0009-7330            Impact factor:   17.367


  8 in total

1.  Direct determination of surface tension in the lung.

Authors:  S Schürch; J Goerke; J A Clements
Journal:  Proc Natl Acad Sci U S A       Date:  1976-12       Impact factor: 11.205

Review 2.  Bioengineering the Blood-gas Barrier.

Authors:  Katherine L Leiby; Micha Sam Brickman Raredon; Laura E Niklason
Journal:  Compr Physiol       Date:  2020-03-12       Impact factor: 9.090

3.  Forced perturbation of respiratory system. B. A continuum mechanics analysis.

Authors:  G W Schmid-Schoenbein; Y C Fung
Journal:  Ann Biomed Eng       Date:  1978-12       Impact factor: 3.934

4.  Functional characteristics of slowly adapting pulmonary stretch receptors in the turtle (Chrysemys picta).

Authors:  D R Jones; W K Milsom
Journal:  J Physiol       Date:  1979-06       Impact factor: 5.182

5.  Mechanics of the lung in the 20th century.

Authors:  Wayne Mitzner
Journal:  Compr Physiol       Date:  2011-10       Impact factor: 9.090

Review 6.  Lung parenchymal mechanics.

Authors:  Béla Suki; Dimitrije Stamenović; Rolf Hubmayr
Journal:  Compr Physiol       Date:  2011-07       Impact factor: 9.090

7.  Prenatal quantification of human foetal lung and liver elasticities between 24 and 39 weeks of gestation using 2D shear wave elastography.

Authors:  Camille Nallet; Lionel Pazart; Claire Cochet; Chrystelle Vidal; Jean-Patrick Metz; Emmanuelle Jacquet; Guillaume Gorincour; Nicolas Mottet
Journal:  Eur Radiol       Date:  2022-03-10       Impact factor: 7.034

Review 8.  The micromechanics of lung alveoli: structure and function of surfactant and tissue components.

Authors:  Lars Knudsen; Matthias Ochs
Journal:  Histochem Cell Biol       Date:  2018-11-02       Impact factor: 4.304

  8 in total

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