Literature DB >> 11829137

Catalog of 77 single-nucleotide polymorphisms (SNPs) in the carbohydrate sulfotransferase 1 (CHST1) and carbohydrate sulfotransferase 3 (CHST3) genes.

Aritoshi Iida1, Susumu Saito, Akihiro Sekine, Chihiro Mishima, Yuri Kitamura, Kimie Kondo, Satoko Harigae, Saori Osawa, Yusuke Nakamura.   

Abstract

Individual phenotypes with respect to drug response or toxicity often result from genetic variations that alter drug metabolism. We have been focusing on genomic loci that encode various enzymes and transporters involved in the metabolism of drugs, and have described more than 1200 single-nucleotide polymorphisms (SNPs) and other variations. Regarding the carbohydrate sulfotransferase (CHST) gene family, we have already constructed high-density SNP maps of three genomic segments that included CHST2, CHST4, and CHST5, providing a total of 28 SNPs for those loci. In the present study, we screened DNA from 48 healthy Japanese volunteers for SNPs at the CHST1 and CHST3 gene loci, by means of direct sequencing combined with a polymerase chain reaction method for amplifying genomic DNA, and characterized 77 SNPs and four insertion-deletion polymorphisms. The collection of human variations presented here adds to the archive of tools now available for investigating complex genetic diseases, population migration patterns, and a variety of pharmacogenetic possibilities.

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Year:  2002        PMID： 11829137     DOI： 10.1007/s10038-002-8650-9

Source DB:  PubMed          Journal:  J Hum Genet        ISSN： 1434-5161            Impact factor:   3.172


  9 in total

1.  Identification of 20 novel SNPs in the guanine nucleotide binding protein alpha 12 gene locus.

Authors:  Aritoshi Iida; Susumu Saito; Akihiro Sekine; Wataru Tabei; Yukie Kataoka; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2004-06-18       Impact factor: 3.172

2.  Inference from the relationships between linkage disequilibrium and allele frequency distributions of 240 candidate SNPs in 109 drug-related genes in four Asian populations.

Authors:  Pei-Chieng Cha; Ryo Yamada; Akihiro Sekine; Yusuke Nakamura; Chong-Lek Koh
Journal:  J Hum Genet       Date:  2004-09-11       Impact factor: 3.172

3.  Catalog of 300 SNPs in 23 genes encoding G-protein coupled receptors.

Authors:  Aritoshi Iida; Susumu Saito; Akihiro Sekine; Yukie Kataoka; Wataru Tabei; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2004-03-20       Impact factor: 3.172

4.  Identification of 156 novel SNPs in 29 genes encoding G-protein coupled receptors.

Authors:  Aritoshi Iida; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2005-04-12       Impact factor: 3.172

5.  Nucleotide variations in genes encoding plasminogen activator inhibitor-2 and serine proteinase inhibitor B10 associated with prostate cancer.

Authors:  Go Shioji; Yoichi Ezura; Toshiaki Nakajima; Kenji Ohgaki; Hiromichi Fujiwara; Yoshinobu Kubota; Tomohiko Ichikawa; Katsuki Inoue; Taro Shuin; Tomonori Habuchi; Osamu Ogawa; Taiji Nishimura; Mitsuru Emi
Journal:  J Hum Genet       Date:  2005-09-20       Impact factor: 3.172

6.  Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.

Authors:  Yuko Fujita; Yoichi Ezura; Mitsuru Emi; Keiko Sato; Daisuke Takada; Yasuhiko Iino; Yasuo Katayama; Kaneo Takahashi; Kouhei Kamimura; Hideaki Bujo; Yasushi Saito
Journal:  J Hum Genet       Date:  2003-12-06       Impact factor: 3.172

7.  Soluble epoxide hydrolase variant (Glu287Arg) modifies plasma total cholesterol and triglyceride phenotype in familial hypercholesterolemia: intrafamilial association study in an eight-generation hyperlipidemic kindred.

Authors:  Keiko Sato; Mitsuru Emi; Yoichi Ezura; Yuko Fujita; Daisuke Takada; Tomoaki Ishigami; Satoshi Umemura; Yunpei Xin; Lily L Wu; Stacey Larrinaga-Shum; Susan H Stephenson; Steven C Hunt; Paul N Hopkins
Journal:  J Hum Genet       Date:  2003-12-13       Impact factor: 3.172

8.  Functional impairment of two novel mutations detected in lipoprotein-associated phospholipase A2 (Lp-PLA2) deficiency patients.

Authors:  Mitsuaki Ishihara; Tadao Iwasaki; Makoto Nagano; Jun Ishii; Mayumi Takano; Takeshi Kujiraoka; Masahiro Tsuji; Hiroaki Hattori; Mitsuru Emi
Journal:  J Hum Genet       Date:  2004-05-18       Impact factor: 3.172

9.  In TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways.

Authors:  Stephen J Lynch; Jiri Zavadil; Angel Pellicer
Journal:  PLoS One       Date:  2013-06-03       Impact factor: 3.240
  9 in total

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