Ramazan Ozcankaya1, Namik Delibas. 1. Department of Psychiatry, University of Suleyman Daniel School of Medicine, Isparta, Turkey,
Abstract
AIM: To investigate the oxidative stress hypothesis in patients with Alzheimer type dementia. METHOD: Serum melatonin, Zn, Cu, Fe, and malondialdehyde (MDA) concentrations and erythrocyte superoxide dismutase (SOD) activity were measured in patients with Alzheimer disease. Mini-Mental State Examination (MMSE) scores were obtained for the patients and their age- and sex-matched healthy controls. RESULTS: MMSE score was 16.81.3 in patients with Alzheimer disease, and 28.22.4 in control group. Melatonin levels were lower in the Alzheimer disease group (170.55.2 pg/mL) than in the control group (205.25.8 pg/mL) (p<0.001). Fe, SOD, and MDA levels were higher in Alzheimer disease group (131.74.8 microg/dL, 1,51090 U/g Hb, and 38.14.7 nmol/mL; respectively) than in the control group (97.14.1 microg/dL, 1,12050 U/g Hb, and 17.21.6 nmol/mL; respectively) (p<0.001 for all comparisons). A statistically significant negative correlation between melatonin and SOD (r=-0.421, p=0.014) and a positive correlation between age and Fe (r=0.325, p=0.049) were found only in the Alzheimer disease group. Correlation between age and melatonin was positive (r=0.481, p=0.006) in Alzheimer disease group and negative (r=-0.472, p=0.009) in the control group. CONCLUSION: Melatonin blood concentration was significantly decreased, and Fe and MDA levels were increased in the patients with Alzheimer disease. We believe that low level of melatonin, especially if there is a simultaneous increase in Fe level, is associated with the development of Alzheimer disease.
AIM: To investigate the oxidative stress hypothesis in patients with Alzheimer type dementia. METHOD: Serum melatonin, Zn, Cu, Fe, and malondialdehyde (MDA) concentrations and erythrocyte superoxide dismutase (SOD) activity were measured in patients with Alzheimer disease. Mini-Mental State Examination (MMSE) scores were obtained for the patients and their age- and sex-matched healthy controls. RESULTS: MMSE score was 16.81.3 in patients with Alzheimer disease, and 28.22.4 in control group. Melatonin levels were lower in the Alzheimer disease group (170.55.2 pg/mL) than in the control group (205.25.8 pg/mL) (p<0.001). Fe, SOD, and MDA levels were higher in Alzheimer disease group (131.74.8 microg/dL, 1,51090 U/g Hb, and 38.14.7 nmol/mL; respectively) than in the control group (97.14.1 microg/dL, 1,12050 U/g Hb, and 17.21.6 nmol/mL; respectively) (p<0.001 for all comparisons). A statistically significant negative correlation between melatonin and SOD (r=-0.421, p=0.014) and a positive correlation between age and Fe (r=0.325, p=0.049) were found only in the Alzheimer disease group. Correlation between age and melatonin was positive (r=0.481, p=0.006) in Alzheimer disease group and negative (r=-0.472, p=0.009) in the control group. CONCLUSION:Melatonin blood concentration was significantly decreased, and Fe and MDA levels were increased in the patients with Alzheimer disease. We believe that low level of melatonin, especially if there is a simultaneous increase in Fe level, is associated with the development of Alzheimer disease.
Authors: Xiongwei Zhu; Hyoung-Gon Lee; Gemma Casadesus; Jesus Avila; Kelly Drew; George Perry; Mark A Smith Journal: Mol Neurobiol Date: 2005 Impact factor: 5.590
Authors: W Jordan; S Cohrs; D Degner; A Meier; A Rodenbeck; G Mayer; J Pilz; E Rüther; J Kornhuber; S Bleich Journal: J Neural Transm (Vienna) Date: 2005-06-15 Impact factor: 3.575
Authors: P K Lam; D Kritz-Silverstein; E Barrett Connor; D Milne; F Nielsen; A Gamst; D Morton; D Wingard Journal: J Nutr Health Aging Date: 2008-01 Impact factor: 4.075
Authors: Ran Furman; Ian V J Murray; Hayley E Schall; Qiwei Liu; Yonatan Ghiwot; Paul H Axelsen Journal: ACS Chem Neurosci Date: 2016-02-09 Impact factor: 4.418
Authors: Rosanna Squitti; Carlo C Quattrocchi; Gloria Dal Forno; Piero Antuono; David R Wekstein; Concetta R Capo; Carlo Salustri; Paolo M Rossini Journal: Biomark Insights Date: 2007-02-07