Literature DB >> 11828434

Crystal structures of orotidine monophosphate decarboxylase: does the structure reveal the mechanism of nature's most proficient enzyme?

K N Houk1, J K Lee, D J Tantillo, S Bahmanyar, B N Hietbrink.   

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Year:  2001        PMID： 11828434     DOI： 10.1002/1439-7633(20010202)2:2<113::AID-CBIC113>3.0.CO;2-T

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  13 in total

1.  Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization.

Authors:  Kui K Chan; B McKay Wood; Alexander A Fedorov; Elena V Fedorov; Heidi J Imker; Tina L Amyes; John P Richard; Steven C Almo; John A Gerlt
Journal:  Biochemistry       Date:  2009-06-23       Impact factor: 3.162

2.  Evolution of the genetic code by incorporation of amino acids that improved or changed protein function.

Authors:  Brian R Francis
Journal:  J Mol Evol       Date:  2013-06-07       Impact factor: 2.395

3.  Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site.

Authors:  Vanessa Iiams; Bijoy J Desai; Alexander A Fedorov; Elena V Fedorov; Steven C Almo; John A Gerlt
Journal:  Biochemistry       Date:  2011-09-06       Impact factor: 3.162

4.  Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme.

Authors:  Bijoy J Desai; B McKay Wood; Alexander A Fedorov; Elena V Fedorov; Bogdana Goryanova; Tina L Amyes; John P Richard; Steven C Almo; John A Gerlt
Journal:  Biochemistry       Date:  2012-10-17       Impact factor: 3.162

5.  Proton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent.

Authors:  Wing-Yin Tsang; B McKay Wood; Freeman M Wong; Weiming Wu; John A Gerlt; Tina L Amyes; John P Richard
Journal:  J Am Chem Soc       Date:  2012-08-21       Impact factor: 15.419

6.  Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution.

Authors:  Bijoy J Desai; Yuki Goto; Alessandro Cembran; Alexander A Fedorov; Steven C Almo; Jiali Gao; Hiroaki Suga; John A Gerlt
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-01       Impact factor: 11.205

7.  Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions.

Authors:  Bogdana Goryanova; Lawrence M Goldman; Tina L Amyes; John A Gerlt; John P Richard
Journal:  Biochemistry       Date:  2013-10-08       Impact factor: 3.162

8.  Using catalytic atom maps to predict the catalytic functions present in enzyme active sites.

Authors:  Geoffrey R Nosrati; K N Houk
Journal:  Biochemistry       Date:  2012-08-30       Impact factor: 3.162

9.  QM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis.

Authors:  Courtney L Stanton; I-Feng W Kuo; Christopher J Mundy; Teodoro Laino; K N Houk
Journal:  J Phys Chem B       Date:  2007-10-10       Impact factor: 2.991

10.  Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: effect of solvent viscosity on kinetic constants.

Authors:  B McKay Wood; Kui K Chan; Tina L Amyes; John P Richard; John A Gerlt
Journal:  Biochemistry       Date:  2009-06-23       Impact factor: 3.162
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