| Literature DB >> 11827725 |
E Rhoden1, C Teloken, M Lucas, C Rhoden, M Mauri, C Zettler, A Bello-Klein, E Barros.
Abstract
The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfunction, and histologic alterations was evaluated during the renal ischemia--reperfusion in uninephrectomized rats. Renal malondialdehyde and serum creatinine levels significantly increased after renal ischemia--reperfusion. However, the pretreatment with allopurinol demonstrated a protector effect in these parameters. Renal ischemia--reperfusion provoked a significant renal damage in the operated group. Tubular atrophy and interstitial fibrosis were attenuated by allopurinol when given prior to the surgery. In our study, allopurinol had a strong tendency to exert a beneficial effect during renal ischemia--reperfusion in uninephrectomized rats.Entities:
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Year: 2000 PMID： 11827725 DOI： 10.1016/s0306-3623(01)00105-7
Source DB: PubMed Journal: Gen Pharmacol ISSN： 0306-3623