Literature DB >> 11827035

Pyloricidins, novel anti-helicobacterpylori antibiotics produced by Bacillus sp. I. Taxonomy, fermentation and biological activity.

M Nakao1, K Miyagaw, Y Nakano, T Sakane, M Tada, O Nishimura, M Fujino.   

Abstract

Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A1, A2, B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric infection caused by H. pylori in Mongolian gerbils and may be promising for cure of H. pylori infection as a single agent.

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Year:  2001        PMID： 11827035     DOI： 10.7164/antibiotics.54.926

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  2 in total

1.  Assembly and clustering of natural antibiotics guides target identification.

Authors:  Chad W Johnston; Michael A Skinnider; Chris A Dejong; Philip N Rees; Gregory M Chen; Chelsea G Walker; Shawn French; Eric D Brown; János Bérdy; Dennis Y Liu; Nathan A Magarvey
Journal:  Nat Chem Biol       Date:  2016-02-01       Impact factor: 15.040

2.  Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics.

Authors:  Tucker Maxson; Douglas A Mitchell
Journal:  Tetrahedron       Date:  2015-10-09       Impact factor: 2.457
  2 in total

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