Literature DB >> 11827033

A new antibiotic CJ-17,665 from Aspergillus ochraceus.

Y Sugie1, H Hirai, T Inagaki, M Ishiguro, Y J Kim, Y Kojima, T Sakakibara, S Sakemi, A Sugiura, Y Suzuki, L Brennan, J Duignan, L H Huang, J Sutcliffe, N Kojima.   

Abstract

A new antibiotic, CJ-17,665 (I) was isolated from the fermentation broth of Aspergillus ochraceus, CL41582. It inhibits growth of multi-drug resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 microg/ml, respectively. The structure contains a diketopiperazine and an indole N-oxide moiety that is unusual in natural products.

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Year:  2001        PMID: 11827033     DOI: 10.7164/antibiotics.54.911

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  21 in total

1.  Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.

Authors:  Xiaoru Wang; Jianlan You; Jarrod B King; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2012-03-08       Impact factor: 4.050

2.  Studies Towards Paraherquamides E & F and Related C-labeled Putative Biosynthetic Intermediates: Stereocontrolled Synthesis of the α-Alkyl-β-Methylproline Ring System.

Authors:  Konrad Sommer; Robert M Williams
Journal:  Tetrahedron       Date:  2008-07-21       Impact factor: 2.457

3.  Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell culture.

Authors:  Jeremy E Wulff; Seth B Herzon; Romain Siegrist; Andrew G Myers
Journal:  J Am Chem Soc       Date:  2007-03-31       Impact factor: 15.419

Review 4.  Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism.

Authors:  Robert M Williams
Journal:  J Org Chem       Date:  2011-04-12       Impact factor: 4.354

5.  Bioinspired chemical synthesis of monomeric and dimeric stephacidin A congeners.

Authors:  Ken Mukai; Danilo Pereira de Sant'Ana; Yasuo Hirooka; Eduardo V Mercado-Marin; David E Stephens; Kevin G M Kou; Sven C Richter; Naomi Kelley; Richmond Sarpong
Journal:  Nat Chem       Date:  2017-09-18       Impact factor: 24.427

Review 6.  Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids.

Authors:  Jennifer M Finefield; Jens C Frisvad; David H Sherman; Robert M Williams
Journal:  J Nat Prod       Date:  2012-04-15       Impact factor: 4.050

7.  Isolation of notoamide E, a key precursor in the biosynthesis of prenylated indole alkaloids in a marine-derived fungus, Aspergillus sp.

Authors:  Sachiko Tsukamoto; Hikaru Kato; Thomas J Greshock; Hiroshi Hirota; Tomihisa Ohta; Robert M Williams
Journal:  J Am Chem Soc       Date:  2009-03-25       Impact factor: 15.419

8.  Chemoselectivity: the mother of invention in total synthesis.

Authors:  Ryan A Shenvi; Daniel P O'Malley; Phil S Baran
Journal:  Acc Chem Res       Date:  2009-04-21       Impact factor: 22.384

9.  The natural product avrainvillamide binds to the oncoprotein nucleophosmin.

Authors:  Jeremy E Wulff; Romain Siegrist; Andrew G Myers
Journal:  J Am Chem Soc       Date:  2007-10-25       Impact factor: 15.419

10.  OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30.

Authors:  Sean A Newmister; Claire M Gober; Stelamar Romminger; Fengan Yu; Ashootosh Tripathi; Lizbeth Lorena L Parra; Robert M Williams; Roberto G S Berlinck; Madeleine M Joullié; David H Sherman
Journal:  J Am Chem Soc       Date:  2016-08-24       Impact factor: 15.419

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