Literature DB >> 11827029

Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus.

R Uchida1, H Tomoda, M Arai, S Omura.   

Abstract

Chlorogentisylquinone, a new inhibitor of neutral sphingomyelinase activity, was purified from the culture broth of a fungal strain FOM-8108 isolated from a marine environment by solvent extraction, silica gel chromatography and Sephadex LH-20 chromatography. Its chemical structure was elucidated by spectroscopic studies including 1H, 13C, DEPT, HMQC and HMBC NMR experiments. Chlorogentisylquinone inhibited neutral sphingomyelinase activity of rat brain membranes with an IC50 value of 1.2 microM.

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Year:  2001        PMID： 11827029     DOI： 10.7164/antibiotics.54.882

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

Review 1.  Marine pharmacology in 2001--2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action.

Authors:  Alejandro M S Mayer; Mark T Hamann
Journal:  Comp Biochem Physiol C Toxicol Pharmacol       Date:  2005 Mar-Apr       Impact factor: 3.228

Review 2.  Novel Sphingolipid-Based Cancer Therapeutics in the Personalized Medicine Era.

Authors:  Jeremy Shaw; Pedro Costa-Pinheiro; Logan Patterson; Kelly Drews; Sarah Spiegel; Mark Kester
Journal:  Adv Cancer Res       Date:  2018-06-19       Impact factor: 6.242

3.  Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties.

Authors:  Mariana Figuera-Losada; Marigo Stathis; Joelle M Dorskind; Ajit G Thomas; Veera Venkata Ratnam Bandaru; Seung-Wan Yoo; Nicholas J Westwood; Graeme W Rogers; Justin C McArthur; Norman J Haughey; Barbara S Slusher; Camilo Rojas
Journal:  PLoS One       Date:  2015-05-26       Impact factor: 3.240

Review 4.  A Review: Halogenated Compounds from Marine Fungi.

Authors:  Cong Wang; Huanyun Lu; Jianzhou Lan; K H Ahammad Uz Zaman; Shugeng Cao
Journal:  Molecules       Date:  2021-01-16       Impact factor: 4.411

5.  Antileishmanial metabolites from Geosmithia langdonii.

Authors:  Lourin G Malak; Mohamed Ali Ibrahim; Daoud W Bishay; Afaf M Abdel-baky; Ahmed M Moharram; Babu Tekwani; Stephen J Cutler; Samir A Ross
Journal:  J Nat Prod       Date:  2014-08-01       Impact factor: 4.050
  5 in total

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