Literature DB >> 11827027

SW-163A and B, novel immunosuppressants produced by Streptomyces sp.

K Takahashi1, E Tsuda, K Kurosawa.   

Abstract

SW-163A and B, novel immunosuppressants, were isolated from the culture broth of Streptomyces sp. SNA15896. The molecular formulas of SW-163A and B were determined as C34H42N2O12 and C33H40N2O12 based on the HRFAB-MS analysis, respectively. Both compounds were elucidated to be a large ring ester structure through spectroscopic analyses including various NMR measurements. SW-163A and B showed immunosuppressive and antimicrobial activities in vitro.

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Year:  2001        PMID： 11827027     DOI： 10.7164/antibiotics.54.867

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  Comprehensive investigation of marine Actinobacteria associated with the sponge Halichondria panicea.

Authors:  Imke Schneemann; Kerstin Nagel; Inga Kajahn; Antje Labes; Jutta Wiese; Johannes F Imhoff
Journal:  Appl Environ Microbiol       Date:  2010-04-09       Impact factor: 4.792

2.  Unantimycin A, a new neoantimycin analog isolated from a microbial metabolite fraction library.

Authors:  Chung Liang Lim; Toshihiko Nogawa; Akiko Okano; Yushi Futamura; Makoto Kawatani; Shunji Takahashi; Darah Ibrahim; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2015-12-09       Impact factor: 2.649

3.  Opantimycin A, a new metabolite isolated from Streptomyces sp. RK88-1355.

Authors:  Toshihiko Nogawa; Akiko Okano; Chung Liang Lim; Yushi Futamura; Takeshi Shimizu; Shunji Takahashi; Darah Ibrahim; Hiroyuki Osada
Journal:  J Antibiot (Tokyo)       Date:  2016-09-07       Impact factor: 2.649

4.  Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras.

Authors:  Angela A Salim; Kwang-Jin Cho; Lingxiao Tan; Michelle Quezada; Ernest Lacey; John F Hancock; Robert J Capon
Journal:  Org Lett       Date:  2014-09-19       Impact factor: 6.005

5.  Neoantimycin F, a Streptomyces-Derived Natural Product Induces Mitochondria-Related Apoptotic Death in Human Non-Small Cell Lung Cancer Cells.

Authors:  Liyun Liu; Hongrui Zhu; Wei Wu; Yaoyao Shen; Xiao Lin; Ying Wu; Li Liu; Jie Tang; Yongjun Zhou; Fan Sun; Hou-Wen Lin
Journal:  Front Pharmacol       Date:  2019-09-18       Impact factor: 5.810
  5 in total

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