| Literature DB >> 11826861 |
Károly Agoston1, Janos Kerékgyártó, János Hajkó, Gyula Batta, Dirk J Lefeber, Johannis P Kamerling, Johannes F G Vliegenthart.
Abstract
The chemical synthesis of alpha-L-Fucp-(1 --> 3)-beta-D-GalpNAc-(1 --> 4)-beta-D-GlcpNAc-(1 --> 3)-alpha-D-GalpO(CH2)5NH2, beta-D-GalpNAc-(1 --> 4)-[alpha-L-Fucp-(1 --> 3)-]beta-D-GlcpNAc-(1 --> 3)-alpha-D-GalpO(CH2)5NH2, and alpha-L-Fucp-(1 --> 3)-beta-D-GalpNAc-(1 --> 4)-[alpha-L-Fucp-(1 --> 3)-]beta-D-GlcpNAc-(1 --> 3)-alpha-D-GalpO(CH2)5NH2 is described. These structures represent fucosylated oligosaccharide fragments of the glycocalyx glycan of the cercarial stage of the parasite Schistosoma mansoni, and in protein-conjugated form they are potential diagnostics in the search for antibodies raised against the glycan in the serum of infected humans.Entities:
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Year: 2002 PMID： 11826861 DOI： 10.1002/1521-3765(20020104)8:1<151::aid-chem151>3.0.co;2-c
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236