Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages.

Literature DB >> 11825872

The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages.

Shireen Saleque¹, Scott Cameron, Stuart H Orkin.

Abstract

Gfi-1 and Gfi-1b are novel proto-oncogenes identified by retroviral insertional mutagenesis. By gene targeting, we establish that Gfi-1b is required for the development of two related blood lineages, erythroid and megakaryocytic, in mice. Gfi-1b(-/-) embryonic stem cells fail to contribute to red cells of adult chimeras. Gfi-1b(-/-) embryos exhibit delayed maturation of primitive erythrocytes and subsequently die with failure to produce definitive enucleated erythrocytes. The fetal liver of mutant mice contains erythroid and megakaryocytic precursors arrested in their development. Myelopoiesis is normal. Therefore, Gfi-1b is an essential transcriptional regulator of erythroid and megakaryocyte development.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2002 PMID： 11825872 PMCID： PMC155332 DOI： 10.1101/gad.959102

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

34 in total

1. The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal.

Authors: H L Grimes; T O Chan; P A Zweidler-McKay; B Tong; P N Tsichlis
Journal: Mol Cell Biol Date: 1996-11 Impact factor: 4.272

2. Erythroid-cell-specific properties of transcription factor GATA-1 revealed by phenotypic rescue of a gene-targeted cell line.

Authors: M J Weiss; C Yu; S H Orkin
Journal: Mol Cell Biol Date: 1997-03 Impact factor: 4.272

3. Structure and erythroid cell-restricted expression of a chicken cDNA encoding a novel zinc finger protein of the Cys + His class.

Authors: B Fuchs; T Wagner; N Rössel; M Antoine; H Beug; J Niessing
Journal: Gene Date: 1997-08-22 Impact factor: 3.688

4. pag-3, a Caenorhabditis elegans gene involved in touch neuron gene expression and coordinated movement.

Authors: Y Jia; G Xie; E Aamodt
Journal: Genetics Date: 1996-01 Impact factor: 4.562

5. The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death.

Authors: H L Grimes; C B Gilks; T O Chan; S Porter; P N Tsichlis
Journal: Proc Natl Acad Sci U S A Date: 1996-12-10 Impact factor: 11.205

6. u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila.

Authors: Y Cubadda; P Heitzler; R P Ray; M Bourouis; P Ramain; W Gelbart; P Simpson; M Haenlin
Journal: Genes Dev Date: 1997-11-15 Impact factor: 11.361

7. Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice.

Authors: B Scheijen; J Jonkers; D Acton; A Berns
Journal: J Virol Date: 1997-01 Impact factor: 5.103

8. Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila.

Authors: M Haenlin; Y Cubadda; F Blondeau; P Heitzler; Y Lutz; P Simpson; P Ramain
Journal: Genes Dev Date: 1997-11-15 Impact factor: 11.361

9. Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development.

Authors: R A Shivdasani; M F Rosenblatt; D Zucker-Franklin; C W Jackson; P Hunt; C J Saris; S H Orkin
Journal: Cell Date: 1995-06-02 Impact factor: 41.582

10. The C. elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1.

Authors: Y Jia; G Xie; J B McDermott; E Aamodt
Journal: Development Date: 1997-05 Impact factor: 6.868

96 in total

1. GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene.

Authors: Duen-Yi Huang; Yuan-Yeh Kuo; Jiann-Shiun Lai; Yutaka Suzuki; Sumio Sugano; Zee-Fen Chang
Journal: Nucleic Acids Res Date: 2004-07-27 Impact factor: 16.971

Review 2. Gfi/Pag-3/senseless zinc finger proteins: a unifying theme?

Authors: Hamed Jafar-Nejad; Hugo J Bellen
Journal: Mol Cell Biol Date: 2004-10 Impact factor: 4.272

3. Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells.

Authors: Cyrus Khandanpour; Ehssan Sharif-Askari; Lothar Vassen; Marie-Claude Gaudreau; Jinfang Zhu; William E Paul; Taro Okayama; Christian Kosan; Tarik Möröy
Journal: Blood Date: 2010-09-08 Impact factor: 22.113

4. Emergence of hematopoietic stem and progenitor cells involves a Chd1-dependent increase in total nascent transcription.

Authors: Fong Ming Koh; Carlos O Lizama; Priscilla Wong; John S Hawkins; Ann C Zovein; Miguel Ramalho-Santos
Journal: Proc Natl Acad Sci U S A Date: 2015-03-23 Impact factor: 11.205

5. Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion.

Authors: Jinfang Zhu; Dragana Jankovic; Alex Grinberg; Liying Guo; William E Paul
Journal: Proc Natl Acad Sci U S A Date: 2006-11-20 Impact factor: 11.205

6. Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.

Authors: Katharina Fiolka; Ronna Hertzano; Lothar Vassen; Hui Zeng; Orit Hermesh; Karen B Avraham; Ulrich Dührsen; Tarik Möröy
Journal: EMBO Rep Date: 2006-01-06 Impact factor: 8.807