Literature DB >> 1182506

Loss of chemoreceptive properties of the rabbit carotid body after destruction of the glomus cells.

A Verna, M Roumy, L M Leitner.   

Abstract

Glomus cells of the rabbit carotid body were destroyed by local freezing. Electrophysiological recording of baroreceptor afferent activities showed that carotid sinus nerve regeneration was completed after 3 months. Nevertheless, ventilatory reaction as well as chemoreceptor afferent activity were no longer observed in response to the usual stimuli of arterial chemoreceptors (O2 test, NaCN). Results support the view that glomus cells are necessary for chemoreception and question the specificity of their afferent innervation.

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Year:  1975        PMID: 1182506     DOI: 10.1016/0006-8993(75)90239-5

Source DB:  PubMed          Journal:  Brain Res        ISSN: 0006-8993            Impact factor:   3.252


  21 in total

1.  Orthodromic spike generation from electrical stimuli in the rat carotid body: implications for the afferent spike generation process.

Authors:  David F Donnelly
Journal:  J Physiol       Date:  2007-01-18       Impact factor: 5.182

Review 2.  Peripheral chemoreceptors: function and plasticity of the carotid body.

Authors:  Prem Kumar; Nanduri R Prabhakar
Journal:  Compr Physiol       Date:  2012-01       Impact factor: 9.090

3.  Modulation of glomus cell membrane currents of intact rat carotid body.

Authors:  D F Donnelly
Journal:  J Physiol       Date:  1995-12-15       Impact factor: 5.182

4.  Carotid chemoreceptor ablation improves survival in heart failure: rescuing autonomic control of cardiorespiratory function.

Authors:  Rodrigo Del Rio; Noah J Marcus; Harold D Schultz
Journal:  J Am Coll Cardiol       Date:  2013-09-04       Impact factor: 24.094

5.  DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity.

Authors:  Jayasri Nanduri; Ying-Jie Peng; Ning Wang; Shakil A Khan; Gregg L Semenza; Nanduri R Prabhakar
Journal:  J Physiol       Date:  2018-01-04       Impact factor: 5.182

Review 6.  Carotid body chemoreceptor function: hypothesis based on a new circuit model.

Authors:  E B Krammer
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

Review 7.  Carotid body function in heart failure.

Authors:  Harold D Schultz; Yu Long Li
Journal:  Respir Physiol Neurobiol       Date:  2007-02-16       Impact factor: 1.931

8.  Dissociation of hypoxia-induced chemosensory responses and catecholamine efflux in cat carotid body superfused in vitro.

Authors:  R Iturriaga; J Alcayaga; P Zapata
Journal:  J Physiol       Date:  1996-12-01       Impact factor: 5.182

9.  Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits.

Authors:  Yanfeng Ding; Yu-Long Li; Harold D Schultz
Journal:  J Appl Physiol (1985)       Date:  2008-03-20

10.  Exercise training improves peripheral chemoreflex function in heart failure rabbits.

Authors:  Yu-Long Li; Yanfeng Ding; Chad Agnew; Harold D Schultz
Journal:  J Appl Physiol (1985)       Date:  2008-06-26
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