Literature DB >> 11824772

A lipid emulsion reduces mortality from clomipramine overdose in rats.

Goor Yoav1, Goor Odelia, Cabilil Shaltiel, Yoav Goor, Odelia Goor, Shaltiel Cabili.   

Abstract

Tricyclic antidepressants are a common cause of self poisoning. Since these drugs are highly lipid soluble, we examined the interaction between imipramine and a lipid emulsion. Rats were given an iv dose of imipramine with either normal saline or a lipid emulsion as vehicle. The rats who received the lipid emulsion had a significantly lower mortality. The role of lipid emulsions poisoning therapy is reviewed.

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Year:  2002        PMID: 11824772

Source DB:  PubMed          Journal:  Vet Hum Toxicol        ISSN: 0145-6296


  8 in total

1.  Intravenous lipid emulsion does not augment blood pressure recovery in a rabbit model of metoprolol toxicity.

Authors:  Alexander Browne; Martyn Harvey; Grant Cave
Journal:  J Med Toxicol       Date:  2010-12

Review 2.  Intravenous fat emulsion: a potential novel antidote.

Authors:  Danielle E Turner-Lawrence; William Kerns Ii
Journal:  J Med Toxicol       Date:  2008-06

Review 3.  Intravenous lipid emulsion in clinical toxicology.

Authors:  Leelach Rothschild; Sarah Bern; Sarah Oswald; Guy Weinberg
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2010-10-05       Impact factor: 2.953

4.  The role of fat emulsion therapy in a rodent model of propranolol toxicity: a preliminary study.

Authors:  Grant Cave; Martyn G Harvey; Craig D Castle
Journal:  J Med Toxicol       Date:  2006-03

Review 5.  Should we consider the infusion of lipid emulsion in the resuscitation of poisoned patients?

Authors:  Grant Cave; Martyn G Harvey
Journal:  Crit Care       Date:  2014-07-30       Impact factor: 9.097

6.  Exploring the effect of intravenous lipid emulsion in acute methamphetamine toxicity.

Authors:  Ameneh Ghadiri; Leila Etemad; Mohammad Moshiri; Seyed Adel Moallem; Amir Hossein Jafarian; Farzin Hadizadeh; Mahmoud Seifi
Journal:  Iran J Basic Med Sci       Date:  2017-02       Impact factor: 2.699

Review 7.  The possible role of intravenous lipid emulsion in the treatment of chemical warfare agent poisoning.

Authors:  Arik Eisenkraft; Avshalom Falk
Journal:  Toxicol Rep       Date:  2016-01-18

8.  Failure of Intravenous Lipid Emulsion to Reduce Diazinon-induced Acute Toxicity: a Pilot Study in Rats.

Authors:  Mohammad Moshiri; Maryam Vahabzadeh; Leila Etemad; Hossein Hosseinzadeh
Journal:  Iran J Pharm Res       Date:  2013       Impact factor: 1.696

  8 in total

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