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Literature DB >> 11824572

Cycloartane glycosides from the rhizomes of Cimicifuga racemosa and their cytotoxic activities.

Kazuki Watanabe¹, Yoshihiro Mimaki, Hiroshi Sakagami, Yutaka Sashida.

Abstract

Phytochemical analysis of the rhizomes of Cimicifuga racemosa (Ranunculaceae) resulted in the isolation of twelve cycloartane glycosides (1--12), including four new ones (4--6, 12). The structures of the new compounds were determined by spectroscopic analysis, including two-dimensional (2D) NMR data, and chemical methods. The isolated compounds were evaluated for their cytotoxic activities against human oral squamous cell carcinoma (HSC-2) cells and normal human gingival fibroblasts (HGF).

Entities: Chemical Disease Gene Species

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Year: 2002 PMID： 11824572 DOI： 10.1248/cpb.50.121

Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645

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Cited

8 in total

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Cycloartane glycosides from the rhizomes of Cimicifuga racemosa and their cytotoxic activities.

1. Metabolic profiling of Actaea species extracts using high performance liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.

2. Growth inhibitory activity of extracts and compounds from Cimicifuga species on human breast cancer cells.

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