| Literature DB >> 11824527 |
K Shrestha1, A H Banskota, S Kodata, S P Shrivastava, G Strobel, M B Gewali.
Abstract
An ethanolic extract of Podocarpus neriifolius D. Don (Podocarpaceae) showed antiproliferative activity against two major tumor cell lines, viz. human HT-1080 fibrosarcoma and murine color 26-L5 carcinoma. Bioassay guided fractionation showed the highest antiproliferative activity in chloroform-soluble fraction. Nagilactone C, the major constituent of this fraction was isolated and characterized by using NMR, IR and FAB-MS spectroscopic methods. Nagilactone C possessed potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 microg/ml, respectively. Hence, nagilactone C could be the active constituent present in this plant.Entities:
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Year: 2001 PMID： 11824527 DOI： 10.1078/S0944-7113(04)70071-9
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340