| Literature DB >> 11823862 |
Keqiang Ye1, Bahman Aghdasi, Hongbo R Luo, John L Moriarity, Frederick Y Wu, Jenny J Hong, K Joseph Hurt, Sun Sik Bae, Pann-Ghill Suh, Solomon H Snyder.
Abstract
Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma 1 also has mitogenic activity upon growth-factor-dependent tyrosine phosphorylation; however, this activity is not dependent on the phospholipase activity of PLC-gamma 1, but requires an SH3 domain. Here, we demonstrate that PLC-gamma 1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity. This enzymatic activity accounts for the mitogenic properties of PLC-gamma 1.Entities:
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Year: 2002 PMID： 11823862 DOI： 10.1038/415541a
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962