Literature DB >> 11823793

No post-genetics era in human disease research.

James Gusella1, Marcy MacDonald.   

Abstract

In the 1980s, linkage emerged as a route to discovering genetic defects, spurring the rise of genomics and making gene-based approaches available to previously phenotype-orientated researchers. In the post-genomics era, genetics is fundamental to understanding disease at all stages of the pathogenic process.

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Year:  2002        PMID： 11823793     DOI： 10.1038/nrg706

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  10 in total

Review 1.  Amyloidogenesis of natively unfolded proteins.

Authors:  Vladimir N Uversky
Journal:  Curr Alzheimer Res       Date:  2008-06       Impact factor: 3.498

2.  Managing juvenile Huntington's disease.

Authors:  Oliver W J Quarrell; Martha A Nance; Peggy Nopoulos; Jane S Paulsen; Jonathan A Smith; Ferdinando Squitieri
Journal:  Neurodegener Dis Manag       Date:  2013-06-01

3.  Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.

Authors:  Marta Biagioli; Francesco Ferrari; Eric M Mendenhall; Yijing Zhang; Serkan Erdin; Ravi Vijayvargia; Sonia M Vallabh; Nicole Solomos; Poornima Manavalan; Ashok Ragavendran; Fatih Ozsolak; Jong Min Lee; Michael E Talkowski; James F Gusella; Marcy E Macdonald; Peter J Park; Ihn Sik Seong
Journal:  Hum Mol Genet       Date:  2015-01-08       Impact factor: 6.150

Review 4.  Studying polyglutamine diseases in Drosophila.

Authors:  Zhen Xu; Antonio Joel Tito; Yan-Ning Rui; Sheng Zhang
Journal:  Exp Neurol       Date:  2015-08-06       Impact factor: 5.330

5.  A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.

Authors:  Sheng Zhang; Richard Binari; Rui Zhou; Norbert Perrimon
Journal:  Genetics       Date:  2010-01-25       Impact factor: 4.562

6.  Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation.

Authors:  Jin Wang; Silvia Gines; Marcy E MacDonald; James F Gusella
Journal:  BMC Neurosci       Date:  2005-01-13       Impact factor: 3.288

7.  Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy.

Authors:  Valentina Fodale; Natalie C Kegulian; Margherita Verani; Cristina Cariulo; Lucia Azzollini; Lara Petricca; Manuel Daldin; Roberto Boggio; Alessandro Padova; Rainer Kuhn; Robert Pacifici; Douglas Macdonald; Ryan C Schoenfeld; Hyunsun Park; J Mario Isas; Ralf Langen; Andreas Weiss; Andrea Caricasole
Journal:  PLoS One       Date:  2014-12-02       Impact factor: 3.240

Review 8.  Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions.

Authors:  April L Darling; Vladimir N Uversky
Journal:  Molecules       Date:  2017-11-24       Impact factor: 4.411

9.  The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease.

Authors:  Jae Whan Keum; Aram Shin; Tammy Gillis; Jayalakshmi Srinidhi Mysore; Kawther Abu Elneel; Diane Lucente; Tiffany Hadzi; Peter Holmans; Lesley Jones; Michael Orth; Seung Kwak; Marcy E MacDonald; James F Gusella; Jong-Min Lee
Journal:  Am J Hum Genet       Date:  2016-02-04       Impact factor: 11.025

Review 10.  Huntington's disease.

Authors:  Marcy E MacDonald; Silvia Gines; James F Gusella; Vanessa C Wheeler
Journal:  Neuromolecular Med       Date:  2003       Impact factor: 4.103
  10 in total

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