| Literature DB >> 11823124 |
Henri J Tochon-Danguy1, John I Sachinidis, Fiona Chan, J Gordon Chan, Catherine Hall, Lawrence Cher, Stan Stylli, John Hill, Andrew Kaye, Andrew M Scott.
Abstract
We have demonstrated that FMISO uptake is significantly higher in tumor tissue in the C6 intracerebral glioma rat model compared to normal brain, and that there is persisting hypoxia in gliomas independent of tumor size. FMISO uptake was observed homogeneously throughout viable glioma tissue in tumor sizes ranging from 2mm to almost 1cm. Quantitation of uptake of FMISO showed a tumor/brain ratio of 1.9 and a tumor/blood ratio of 2.6 at 2 hours post injection.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11823124 DOI： 10.1016/s0969-8051(01)00298-0
Source DB: PubMed Journal: Nucl Med Biol ISSN： 0969-8051 Impact factor: 2.408