BACKGROUND: The role of selected micronutrients, vitamins and minerals in the aetiology of epithelial ovarian cancer was investigated using data from a case-control study conducted between 1992 and 1999 in five Italian areas. PATIENTS AND METHODS: Cases were 1,031 patients with histologically confirmed incident epithelial ovarian cancer. Controls were 2,411 subjects admitted for acute, non-neoplastic diseases to major hospitals in the same catchment areas. Dietary habits were elicited using a validated food frequency questionnaire including 78 food groups and recipes. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed by quintiles of intake of nutrients. RESULTS: Inverse associations emerged for vitamin E (OR = 0.6; 95% CI: 0.5-0.8), beta-carotene (OR = 0.8; 95% CI: 0.6-1.0), lutein/zeaxanthin (OR = 0.6; 95% CI: 0.5-0.8 for the highest vs. the lowest quintile of intake), and calcium intake (OR = 0.7; 95% CI: 0.6-1.0). When the combined effect of calcium and vitamin E was considered, the OR reached 0.4 (95% CI: 0.3-0.7) for subjects in the highest compared to those in the lowest intake tertile of both micronutrients. Results were consistent across strata of menopausal status, parity and family history of ovarian or breast cancer. CONCLUSIONS: The intake of selected micronutrients, which were positively correlated to a diet rich in vegetables and fruits, was inversely associated with ovarian cancer.
BACKGROUND: The role of selected micronutrients, vitamins and minerals in the aetiology of epithelial ovarian cancer was investigated using data from a case-control study conducted between 1992 and 1999 in five Italian areas. PATIENTS AND METHODS: Cases were 1,031 patients with histologically confirmed incident epithelial ovarian cancer. Controls were 2,411 subjects admitted for acute, non-neoplastic diseases to major hospitals in the same catchment areas. Dietary habits were elicited using a validated food frequency questionnaire including 78 food groups and recipes. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed by quintiles of intake of nutrients. RESULTS: Inverse associations emerged for vitamin E (OR = 0.6; 95% CI: 0.5-0.8), beta-carotene (OR = 0.8; 95% CI: 0.6-1.0), lutein/zeaxanthin (OR = 0.6; 95% CI: 0.5-0.8 for the highest vs. the lowest quintile of intake), and calcium intake (OR = 0.7; 95% CI: 0.6-1.0). When the combined effect of calcium and vitamin E was considered, the OR reached 0.4 (95% CI: 0.3-0.7) for subjects in the highest compared to those in the lowest intake tertile of both micronutrients. Results were consistent across strata of menopausal status, parity and family history of ovarian or breast cancer. CONCLUSIONS: The intake of selected micronutrients, which were positively correlated to a diet rich in vegetables and fruits, was inversely associated with ovarian cancer.
Authors: Kathryn L Terry; Shelley S Tworoger; Ellen L Goode; Margaret A Gates; Linda Titus-Ernstoff; Linda E Kelemen; Thomas A Sellers; Susan E Hankinson; Daniel W Cramer Journal: Gynecol Oncol Date: 2010-11 Impact factor: 5.482
Authors: Rupert Lloyd Hough; Tony Fletcher; Giovanni Sebastiano Leonardi; Walter Goessler; Patrizia Gnagnarella; Felicity Clemens; Eugen Gurzau; Kvetoslava Koppova; Peter Rudnai; Rajiv Kumar; Marie Vahter Journal: Int Arch Occup Environ Health Date: 2010-04-17 Impact factor: 3.015
Authors: Anita Koushik; Molin Wang; Kristin E Anderson; Piet van den Brandt; Tess V Clendenen; A Heather Eliassen; Jo L Freudenheim; Jeanine M Genkinger; Niclas Håkansson; James R Marshall; Marjorie L McCullough; Anthony B Miller; Kim Robien; Thomas E Rohan; Catherine Schairer; Leo J Schouten; Shelley S Tworoger; Ying Wang; Alicja Wolk; Anne Zeleniuch-Jacquotte; Stephanie A Smith-Warner Journal: Cancer Causes Control Date: 2015-07-14 Impact factor: 2.506
Authors: Paul D Terry; Bo Qin; Fabian Camacho; Patricia G Moorman; Anthony J Alberg; Jill S Barnholtz-Sloan; Melissa Bondy; Michele L Cote; Ellen Funkhouser; Kristin A Guertin; Edward S Peters; Ann G Schwartz; Joellen M Schildkraut; Elisa V Bandera Journal: J Nutr Date: 2017-02-15 Impact factor: 4.798
Authors: Wei Zheng; Kim N Danforth; Shelley S Tworoger; Marc T Goodman; Alan A Arslan; Alpa V Patel; Marjorie L McCullough; Stephanie J Weinstein; Laurence N Kolonel; Mark P Purdue; Xiao-Ou Shu; Kirk Snyder; Emily Steplowski; Kala Visvanathan; Kai Yu; Anne Zeleniuch-Jacquotte; Yu-Tang Gao; Susan E Hankinson; Chinonye Harvey; Richard B Hayes; Brian E Henderson; Ronald L Horst; Kathy J Helzlsouer Journal: Am J Epidemiol Date: 2010-06-18 Impact factor: 4.897
Authors: Nitin Shivappa; James R Hébert; Valentina Rosato; Marta Rossi; Maurizio Montella; Diego Serraino; Carlo La Vecchia Journal: Cancer Causes Control Date: 2016-06-04 Impact factor: 2.506
Authors: Joanne Kotsopoulos; Jonathan L Hecht; Jonathan D Marotti; Linda E Kelemen; Shelley S Tworoger Journal: Int J Cancer Date: 2010-05-01 Impact factor: 7.396
Authors: Alan A Arslan; Tess V Clendenen; Karen L Koenig; Johan Hultdin; Kerstin Enquist; Asa Agren; Annekatrin Lukanova; Hubert Sjodin; Anne Zeleniuch-Jacquotte; Roy E Shore; Göran Hallmans; Paolo Toniolo; Eva Lundin Journal: J Oncol Date: 2009-08-27 Impact factor: 4.375